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Titolo:
Aspiration cytopathology of middle-ear neuroendocrine carcinoma
Autore:
Menezes, G; Wakely, P;
Indirizzi:
Ohio State Univ, Med Ctr, Dept Pathol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Dept Pathol, Columbus, OH 43210 USA
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 168 - 171
SICI:
8755-1039(200109)25:3<168:ACOMNC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR; HISTOGENESIS; ADENOMA;
Keywords:
neuroendocrine carcinoma; middle ear; carcinoid tumor; fine-needle aspiration biopsy; cytopathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Wakely, P Ohio State Univ, Med Ctr, Dept Pathol, 414 Doan Hall,410 W 10th Ave, Columbus, OH 43210 USA Ohio State Univ 414 Doan Hall,410 W 10th Ave Columbus OH USA 43210
Citazione:
G. Menezes e P. Wakely, "Aspiration cytopathology of middle-ear neuroendocrine carcinoma", DIAGN CYTOP, 25(3), 2001, pp. 168-171

Abstract

Primary neuroendocrine carcinoma (carcinoid tumor) is among the rarest of middle-ear (ME) neoplasms, with only a rare case of metastatic disease having been reported. Fine-needle aspiration biopsy (FNAB) was performed in a 51-yr-old male with a two-decade history of multiple local recurrences from a right middle-ear neoplasm, with the most recent surgical excision 2 yr ago. He currently presented with an enlarged right parotid gland, and a rightinfratemporal mass. Aspirate smears showed a monotonous population of cytologically bland cells with a small to moderate amount of pale granular cytoplasm, round to oval nuclei, inconspicuous nucleoli, and finely granular chromatin. Rare, isolated large cells were occasionally seen. Immunohistochemical staining of the cell block made from the aspirated material showed strong cytoplasmic positivity for chromogranin, synaptophysin, neuron-specificenolase (NSE), serotonin, and cytokeratin cocktail, and negative staining for S100 protein. Review of tissue slides from the patient's prior middle-ear tumor showed an identical immunoprofile and morphology, and led to a revision of the original diagnosis of paraganglioma. Middle-ear neuroendocrinecarcinoma has a low but definite metastatic potential, which can be diagnosed using FNAB if ancillary immunohistochemical studies are available. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 17:52:38