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Titolo:
Endothelial perturbation in children and adolescents with type 1 diabetes - Association with markers of the inflammatory reaction
Autore:
Romano, M; Pomilio, M; Vigneri, S; Falco, A; Chiesa, PL; Chiarelli, F; Davi, G;
Indirizzi:
Univ Messina, Dept Human Pathol, I-98100 Messina, Italy Univ Messina Messina Italy I-98100 Human Pathol, I-98100 Messina, Italy Univ Chieti, Dept Med & Aging, Div Pediat, Chieti, Italy Univ Chieti Chieti Italy i, Dept Med & Aging, Div Pediat, Chieti, Italy Univ Palermo, Dept Med, I-90133 Palermo, Italy Univ Palermo Palermo Italy I-90133 rmo, Dept Med, I-90133 Palermo, Italy Univ Chieti, Dept Med & Aging, Div Hematol, Chieti, Italy Univ Chieti Chieti Italy , Dept Med & Aging, Div Hematol, Chieti, Italy Univ Chieti, Dept Med & Aging, Div Pediat Surg, Chieti, Italy Univ ChietiChieti Italy pt Med & Aging, Div Pediat Surg, Chieti, Italy
Titolo Testata:
DIABETES CARE
fascicolo: 9, volume: 24, anno: 2001,
pagine: 1674 - 1678
SICI:
0149-5992(200109)24:9<1674:EPICAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VON-WILLEBRAND-FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; VASCULAR ENDOTHELIUM; DYSFUNCTION; ACTIVATION; BIOSYNTHESIS; PATHOGENESIS; PHYSIOLOGY; ANTIBODIES; ANGIOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Davi, G Univ Chieti, Cattedra Ematol, Via dei Vestini 31, I-66013 Chieti, Italy Univ Chieti Via dei Vestini 31 Chieti Italy I-66013 Chieti, Italy
Citazione:
M. Romano et al., "Endothelial perturbation in children and adolescents with type 1 diabetes - Association with markers of the inflammatory reaction", DIABET CARE, 24(9), 2001, pp. 1674-1678

Abstract

OBJECTIVE - The progression of diabetic angiopathy is, in most cases, unpredictable. The aim of this study was to investigate early events that couldinfluence the development of diabetic angiopathy. RESEARCH DESIGN AND METHODS - Circulating levels of von Willebrand factor (vWF) and tissue-plasminogen activator (tPA), defining endothelial perturbation, were measured in 40 young patients With type I diabetes. Patients were divided into two groups according to the duration of diabetes (group A, <1 year; group B, >1 year) and compared with a control group of age- and sex-matched healthy individuals. Prothrombin fragment I and 2 (F1+2), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) levels were also determined as markers of a prothrombotic state and inflammatory response. A total of 16 of the 20 children in group A Were Te-examined after 12 months. RESULTS - Compared with either normal subjects or patients in group B, children in group A showed increased levels of wWF, tPA, F1+2, TNF-alpha, and CRP. Significant direct correlations, between TNT-alpha or CRP and either wWF, tPA, or F1+2 were observed. Endothelial perturbation was shown in 70% of group A and 20% of group B. After I year, 16 of the 20 patients in group A showed a significant reduction in vWF, tPA, F1+2, TNF-alpha, and CRP levels, Whereas endothelial perturbation was reversed in 5 of these patients. CONCLUSIONS - Endothelial perturbation represents an early and, in some cases, reversible event in the chronology of type I diabetes in children. A correlation might exist between the initial inflammatory reaction and the appearance of endothelial perturbation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:47:07