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Titolo:
The Krox-20 null mutation differentially affects the development of masticatory muscles
Autore:
Turman, JE; Chopiuk, NB; Shuler, CF;
Indirizzi:
Univ So Calif, Dept Biokinesiol & Phys Therapy, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Therapy, Los Angeles, CA 90089 USA Univ So Calif, Sch Dent, Ctr Craniofacial Mol Biol, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 ol Biol, Los Angeles, CA 90089 USA
Titolo Testata:
DEVELOPMENTAL NEUROSCIENCE
fascicolo: 2, volume: 23, anno: 2001,
pagine: 113 - 121
SICI:
0378-5866(200103/04)23:2<113:TKNMDA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZINC-FINGER GENE; SEGMENTAL EXPRESSION; DEVELOPING HINDBRAIN; TYROSINE KINASE; MOTOR NUCLEI; MICE; REGION; GROWTH; MOUSE; REORGANIZATION;
Keywords:
trigeminal motor nucleus; suckling; branchial motoneurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Turman, JE Univ So Calif, Dept Biokinesiol & Phys Therapy, 1540 E Alcazar St,CHP155, Los Angeles, CA 90089 USA Univ So Calif 1540 E Alcazar St,CHP155Los Angeles CA USA 90089
Citazione:
J.E. Turman et al., "The Krox-20 null mutation differentially affects the development of masticatory muscles", DEV NEUROSC, 23(2), 2001, pp. 113-121

Abstract

The Krox-20 null mutation results in a loss of rhombomeres 3 and 5, which give rise to neurons that are essential to oral motor behaviors. Thus, the Krox-20 null mutant is an excellent model to investigate the development oforal motor circuitry. Our morphological examination of embryonic and neonatal Krox-20 null mutants revealed that a significant reduction of anterior digastric, and mylohyoid muscles, the primary jaw openers, occurs between embryonic days 15 and 19. There are no gross morphological alterations in other masticatory muscles. These findings demonstrate that Krox-20 expressionis critical for the normal development of the primary jaw opener musculature and they help explain previous studies documenting a reduction in jaw opening in Krox-20 null mutants. Since jaw opening is the power stroke of suckling behavior, our data help explain the reduction of colostrum/milk ingestion in Krox-20 null mutant neonates. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:53:07