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Titolo:
The evolution of assays for parathyroid hormone
Autore:
Martin, KJ; Gonzalez, EA;
Indirizzi:
St Louis Univ, Div Nephrol, Sch Med, Dept Internal Med, St Louis, MO 63110USA St Louis Univ St Louis MO USA 63110 t Internal Med, St Louis, MO 63110USA
Titolo Testata:
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
fascicolo: 5, volume: 10, anno: 2001,
pagine: 569 - 574
SICI:
1062-4821(200109)10:5<569:TEOAFP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNORADIOMETRIC ASSAY; CALCIUM-CONCENTRATION; CLINICAL UTILITY; BINDING-SITES; FRAGMENTS; PTH; METABOLISM; INVIVO; CELLS; RAT;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, KJ St Louis Univ, Div Nephrol, Sch Med, Dept Internal Med, 3635 Vista Ave, StLouis, MO 63110 USA St Louis Univ 3635 Vista Ave St Louis MO USA63110 MO 63110 USA
Citazione:
K.J. Martin e E.A. Gonzalez, "The evolution of assays for parathyroid hormone", CURR OP NEP, 10(5), 2001, pp. 569-574

Abstract

Recent progress in the assay of parathyroid hormone has revealed that commercially available assays for intact parathyroid hormone also measure additional parathyroid hormone peptides that appear to be truncated at the amino-terminal region and have the elution position on highperformance liquid chromatography of parathyroid hormone 7-84. Specific assays have been developed that measure only the true or 'whole', 84-amino-acid peptide. Such 'whole' parathyroid hormone assays have led to the discovery of new findings that suggest that parathyroid hormone fragments such as parathyroid hormone 7-84, which have hitherto been considered to be biologically inactive, may actually have biologic effects. These data, coupled with the emerging discovery of additional receptors for parathyroid hormone peptides, suggest that parathyroid hormone fragments might have potentially important actions, at least in the setting of renal failure. Curr Opin Nephrol Hypertens 10:569-574. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:31:40