Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Survey of factor V Leiden and prothrombin gene mutations in systemic lupuserythematosus
Autore:
Topaloglu, R; Akierli, C; Bakkaloglu, A; Aydintug, O; Ozen, S; Besbas, N; Ozcelik, T;
Indirizzi:
Hacettepe Univ, Fac Med, Dept Pediat Nephrol & Rheumatol, TR-06100 Ankara,Turkey Hacettepe Univ Ankara Turkey TR-06100 Rheumatol, TR-06100 Ankara,Turkey
Titolo Testata:
CLINICAL RHEUMATOLOGY
fascicolo: 4, volume: 20, anno: 2001,
pagine: 259 - 261
SICI:
0770-3198(2001)20:4<259:SOFVLA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
COAGULATION-FACTOR-V; ACTIVATED PROTEIN-C; VENOUS THROMBOSIS; ANTIPHOSPHOLIPID ANTIBODIES; RISK; RESISTANCE; COMMON;
Keywords:
factor V Leiden; gene mutation; prothrombin; SLE; systemic lupus erythematosus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Topaloglu, R Hacettepe Univ, Fac Med, Dept Pediat Nephrol & Rheumatol, TR-06100 Ankara,Turkey Hacettepe Univ Ankara Turkey TR-06100 R-06100 Ankara,Turkey
Citazione:
R. Topaloglu et al., "Survey of factor V Leiden and prothrombin gene mutations in systemic lupuserythematosus", CLIN RHEUMA, 20(4), 2001, pp. 259-261

Abstract

The two most common hereditary risk factors for thrombosis are factor V Leiden mutation and a prothrombin gene mutation. There is indeed a thrombotictendency in patients with systemic lupus erythematosis (SLE) and it is notalways associated with antiphospholipid antibodies. We aimed to determine the relationship between both factor V Leiden and prothrombin gene mutations and SLE. Using polymerase chain reaction (PCR) the factor V Leiden and prothrombin gene mutations were evaluated in 55 patients (20 children and 35 adults) with SLE. Although seven patients were found to have factor V Leiden mutation in the heterozygous state, two had the heterozygous G --> A (20210) prothrombin gene mutation. Although one had these two mutations concurrently, these two patients did not have thrombosis. The factor V Leiden mutation frequency (12.7%) was higher than that of our general population (7.1%). On the other hand, seven of the patients with SLE had a thrombotic event. Although of these seven, four (57%) had factor V Leiden mutation, three (43%) had no mutation. Of 48 patients with no thrombotic history, only threehad the factor V mutation (6.25%). The prevalence of the factor V Leiden mutation in SLE patients with and without thrombosis was significantly different by Fisher's exact test (p <0.05). The risk of venous thrombosis in patients with factor V Leiden increased threefold compared to that in those without factor V Leiden mutation (odds ratio 20.1; Cl 2.99-133.6). Although factor V Leiden mutation seems to play a role in the development of venous thrombosis in SLE, the development of thrombosis in SLE is multifactorial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:35:04