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Titolo:
Enhanced associated movements in the contralateral limbs elicited by briskvoluntary contraction in choreic disorders
Autore:
Hashimoto, T; Shindo, M; Yanagisawa, N;
Indirizzi:
Shinshu Univ, Sch Med, Dept Med Neurol 3, Matsumoto, Nagano 3908621, JapanShinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Shinshu Univ, Ctr Hlth Serv, Matsumoto, Nagano 390, Japan Shinshu Univ Matsumoto Nagano Japan 390 erv, Matsumoto, Nagano 390, Japan Natl Inst Longev, Obu, Japan Natl Inst Longev Obu JapanNatl Inst Longev, Obu, Japan
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 9, volume: 112, anno: 2001,
pagine: 1612 - 1617
SICI:
1388-2457(200109)112:9<1612:EAMITC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIA; HUNTINGTONS-DISEASE; INTRACORTICAL INHIBITION; PRIMATE MODELS; L-DOPA; DYSKINESIA; POTENTIALS; MONKEY; PET;
Keywords:
associated movement; chorea; dyskinesia; Huntington's disease; Parkinson's disease; spinocerebellar degeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, T Shinshu Univ, Sch Med, Dept Med Neurol 3, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan Shinshu Univ 3-1-1 Asahi Matsumoto Nagano Japan 3908621 Japan
Citazione:
T. Hashimoto et al., "Enhanced associated movements in the contralateral limbs elicited by briskvoluntary contraction in choreic disorders", CLIN NEU, 112(9), 2001, pp. 1612-1617

Abstract

Objectives: To study the deficit of inhibition of excessive motor drive generated in the central nervous system in chorea. Methods: Identical associated movements in the contralateral limb elicitedby rapid hand squeezing were measured in 6 patients with Huntington's disease, 7 patients with peak-dose dyskinesia, 10 patients with Parkinson's disease, 8 patients with spinocerebellar degeneration and in 8 normal subjects. The intensity of associated movements was assessed by the EMG amplitude ratio of associated contractions to active contractions. Results: The associated movement ratios were larger in Huntington's disease and peak-dose dyskinesia as compared to other groups. The ratios in akinetic 'off' phase were smaller than those in dyskinetic 'on' phase in all peak-dose dyskinesia patients. Conclusions: Enhanced associated movements support a possible common mechanism that chorea may result from failure in inhibition of phasic neural activity pathologically generated in the brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 07:24:07