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Titolo:
Regularity of force tremor in Parkinson's disease
Autore:
Vaillancourt, DE; Slifkin, AB; Newell, KM;
Indirizzi:
Penn State Univ, Dept Kinesiol, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 l, University Pk, PA 16802 USA Penn State Univ, Gerontol Ctr, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 r, University Pk, PA 16802 USA Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 h, University Pk, PA 16802 USA
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 9, volume: 112, anno: 2001,
pagine: 1594 - 1603
SICI:
1388-2457(200109)112:9<1594:ROFTIP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TIME-SERIES; FINGER TREMOR; 40 HZ; COMPLEXITY;
Keywords:
force tremor; Parkinson's disease; regularity; time series; unified Parkinson's disease rating scale;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Vaillancourt, DE Univ Illinois, Sch Kinesiol MC 194, 901 W Roosevelt Rd, Chicago, IL 60608 USA Univ Illinois 901 W Roosevelt Rd Chicago IL USA 60608 USA
Citazione:
D.E. Vaillancourt et al., "Regularity of force tremor in Parkinson's disease", CLIN NEU, 112(9), 2001, pp. 1594-1603

Abstract

Objectives: The study examines the time-dependent structure of force tremor to investigate two hypotheses: (1), the regularity of tremor can help in discriminating normal aging from that of Parkinson's disease (PD); and (2),there is increased tremor regularity with increases. in the severity of PD. Methods: Eight young (21-29 years), eight elderly (68-80 years), and eightPD (68-80 years) subjects produced constant grip force at 5, 25 and 50% oftheir maximal voluntary contraction by squeezing two load cells with theirindex finger and thumb under a vision and no vision condition. Spectral analysis. and approximate entropy (ApEn) were used, respectively, to analyze the frequency and time-dependent structure of tremor. Results: The analyses showed that there were no differences in the amplitude and modal frequency of force tremor between groups. The ApEn was significantly lower in the PD group compared with the controls. For the PD group, the linear relations between the total scores taken from the Unified Parkinson's Disease Rating Scale-motor section and the dependent variables were r(2) = 0.71 (P < 0.01) for ApEn, r(2) = 0.20 (P > 0.05) for the modal frequency, and r(2) = 0.23 (P > 0.05) for the standard deviation. Surrogate analyses revealed that the time-dependent structure of tremor provided additional information beyond that of amplitude and modal frequency analyses. Conclusions: These findings indicate that tremor analyses should not be limited to just the frequency and amplitude of the oscillation, and that the time-dependent structure of tremor is useful in differentiating tremor in healthy people from those with PD. The hypothesis that more regular tremor in PD is due to a loss of multiple neuronal oscillators contributing to the tremor output is discussed. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:14:45