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Titolo:
Excitability of human axons
Autore:
Burke, D; Kiernan, MC; Bostock, H;
Indirizzi:
Univ New S Wales, Prince Wales Med Res Inst, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia d Res Inst, Sydney, NSW, Australia Prince Wales Hosp, Dept Neurol, Sydney, NSW, Australia Prince Wales Hosp Sydney NSW Australia pt Neurol, Sydney, NSW, Australia Inst Neurol, Sobell Dept Neurophysiol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG urophysiol, London WC1N 3BG, England
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 9, volume: 112, anno: 2001,
pagine: 1575 - 1585
SICI:
1388-2457(200109)112:9<1575:EOHA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CUTANEOUS AFFERENTS; STRENGTH-DURATION PROPERTIES; HUMAN MOTOR AXONS; AMYOTROPHIC-LATERAL-SCLEROSIS; HUMAN PERIPHERAL-NERVE; HIGH-FREQUENCY STIMULATION; LIZARD MYELINATED AXONS; SQUAMOUS-CELL CARCINOMA; CARPAL-TUNNEL SYNDROME; GATED SODIUM-CHANNELS;
Keywords:
axonal excitability; recovery cycle; threshold electrotonus; depolarization; hyperpolarization;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Burke, D Prince Wales Med Res Inst, Barker St, Randwick, NSW 2031, Australia Prince Wales Med Res Inst Barker St Randwick NSW Australia 2031 a
Citazione:
D. Burke et al., "Excitability of human axons", CLIN NEU, 112(9), 2001, pp. 1575-1585

Abstract

The excitability of human axons can be studied reliably using the technique of threshold tracking, which allows the strength of a test stimulus to beadjusted by computer to activate a defined fraction of the maximal nerve or muscle action potential. The stimulus current that just evokes the targetresponse is considered the 'threshold' for that response. More useful thanthe resting threshold are other indices of axonal excitability derived from pairs of threshold measurements, such as refractoriness, supernormality, strength-duration time constant and 'threshold electrotonus' (i.e. the changes in threshold produced by long-lasting depolarizing or hyperpolarizing current pulses). Each of these measurements depends on membrane potential and on other biophysical properties of the axons. Together they can provide new information about the pathophysiology underlying abnormalities in excitability in neuropathy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:29:51