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Titolo:
Peripheral microcirculation during pregnancy and in women with pregnancy induced hypertension
Autore:
Ohlmann, P; Jung, F; Mrowietz, C; Alt, T; Alt, S; Schmidt, W;
Indirizzi:
Univ Saarland, Dept Obstet & Gynecol, D-6650 Homburg, Germany Univ Saarland Homburg Germany D-6650 & Gynecol, D-6650 Homburg, Germany Dresden Inst Cardiovasc Res, Dresden, Germany Dresden Inst Cardiovasc ResDresden Germany ovasc Res, Dresden, Germany
Titolo Testata:
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
fascicolo: 3, volume: 24, anno: 2001,
pagine: 183 - 191
SICI:
1386-0291(2001)24:3<183:PMDPAI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIDEO CAPILLARY MICROSCOPY; PROSTACYCLIN PRODUCTION; FETAL GROWTH; BLOOD; PROSTAGLANDINS; PREECLAMPSIA; MECHANISMS; REACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ohlmann, P Marienkrankenhaus Papenburg Aschendorf, Dept Obstet & Gynecol, Hauptkanal 75, D-26871 Papenburg, Germany Marienkrankenhaus Papenburg Aschendorf Hauptkanal 75 Papenburg Germany D-26871
Citazione:
P. Ohlmann et al., "Peripheral microcirculation during pregnancy and in women with pregnancy induced hypertension", CL HEMORH M, 24(3), 2001, pp. 183-191

Abstract

During pregnancy the cardiovascular system undergoes several changes so asto adapt the maternal organism to the strains of pregnancy. These adaptations can assume a pathological development in persons with a previous history of cardiovascular problems. On the other hand the absence of these adaptations may lead to a pathological course of pregnancy. Pregnancy induced hypertension (PIH) may be such a pathological development due to maladaptation. The causes are for the most part unknown. For some time it has been assumed that it is due to microcirculatory disorders. Using periungual capillarymicroscopy the present study prospectively investigated the changes in peripheral microcirculation during pregnancy focusing on pregnancy induced hypertension. Sixty-seven women with a normal course of pregnancy and 28 womenwith pregnancy induced hypertension were evaluated. Throughout the prospective study 3 examinations were performed during pregnancy and one during childbed. The women who developed a PIH were registered during the third trimester. Erythrocyte velocity at rest and vascular reagibility of capillariesfollowing a 3 minute ischaemia were evaluated. In the course of pregnancy a significant increase of approximately 30% in erythrocyte velocity could be observed. Interpolation to obtain the best strait line result demonstrates that it is a continuous increase. Erythrocyte velocity returns to normal in the course of 14 weeks post partum. Due to a physiological vasodilatation during pregnancy, vascular reaction to ischaemic stress significantly decreases. During childbed these changes return to normal. Examinations on women with pregnancy induced hypertension not only showed a significant reduction of microcirculation under resting conditions but also a different pattern of reaction to ischaemic stress. Erythrocyte velocity under resting conditions lies 36% below normal values. Furthermore the distinctly shortened hyperaemic period indicates a hightened sensitivity to vasoconstrictive substances in women with PIH. While taking into account the clinical data a positive correlation with the severity of the illness was able to be established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:44:16