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Titolo:
Hemorheological effects of sodium fluorescein in rats
Autore:
Sargento, L; do Rosario, HS; Saldanha, C; Martins-Silva, J;
Indirizzi:
Univ Lisbon, Fac Med, Inst Biochem, P-1649028 Lisbon, Portugal Univ Lisbon Lisbon Portugal P-1649028 iochem, P-1649028 Lisbon, Portugal
Titolo Testata:
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
fascicolo: 3, volume: 24, anno: 2001,
pagine: 175 - 181
SICI:
1386-0291(2001)24:3<175:HEOSFI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING; BLOOD; ANGIOGRAPHY; PLASMA; EOSIN;
Keywords:
sodium fluorescein; plasma viscosity; erythrocyte membrane; membrane fluidity; carboxyhemoglobin; erythrocyte deformability; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Sargento, L Univ Lisbon, Fac Med, Inst Biochem, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal Univ Lisbon Av Prof Egas Moniz Lisbon Portugal P-1649028 ugal
Citazione:
L. Sargento et al., "Hemorheological effects of sodium fluorescein in rats", CL HEMORH M, 24(3), 2001, pp. 175-181

Abstract

Sodium fluorescein is widely used in clinical practice for the study of the retinal circulation by angiography. It has been reported several hemorheological and microvascular abnormalities induced by this compound. The aim of this work was to analyse the hemorheological effects of intravenous sodium fluorescein in an animal model. Twenty male 10-16 weeks-old Wistar rats were used, under systemic anaesthesia. The animals were divided in 2 groups of 10 each: (1) intravenous injection of sodium fluorescein (14 mg/kg of body weight)-Group NaF, (2) controls (injection of NaCl 0.9%)-Group CTRL. A blood sample was drawn by aortic puncture after 60 minutes and hemorheological parameters determined: hematocrit, hemoglobin, metahemoglobin, carboxyhemoglobin, plasma viscosity, erythrocyte deformability, membrane fluidity and acetylcholinesterase activity. In the Group NaF there was a 20% reductionof the AChE activity (p<0.05) and an increase in PV (p<0.05). Concerning hemoglobin status, a three-fold increase in COHb (p<0.001) was shown. In conclusion, the NaF injection in the animal model produces hemorheological abnormalities similar to those reported in the human.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:57:00