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Titolo:
Effects of administration of glycoprotein IIb/IIIa receptor antagonists inpatients with failed thrombolysis - A pilot study
Autore:
Di Pasquale, P; Sarullo, FM; Cannizzaro, S; Vitrano, MG; Vincenzo, B; Giambanco, F; Scandurra, A; Calcaterra, G; Paterna, S;
Indirizzi:
GF Ingrassia Hosp, Div Cardiol Paolo Borsellino, Palermo, Italy GF Ingrassia Hosp Palermo Italy ardiol Paolo Borsellino, Palermo, Italy Buccheri La Ferla Hosp, Div Cardiol, Palermo, Italy Buccheri La Ferla Hosp Palermo Italy Hosp, Div Cardiol, Palermo, Italy Civ Hosp, Haemodynam Serv, Palermo, Italy Civ Hosp Palermo ItalyCiv Hosp, Haemodynam Serv, Palermo, Italy Civ Hosp, Div Anaesthesiol, Palermo, Italy Civ Hosp Palermo ItalyCiv Hosp, Div Anaesthesiol, Palermo, Italy Univ Palermo, Dept Internal Med, Palermo, Italy Univ Palermo Palermo Italy v Palermo, Dept Internal Med, Palermo, Italy
Titolo Testata:
CLINICAL DRUG INVESTIGATION
fascicolo: 8, volume: 21, anno: 2001,
pagine: 545 - 553
SICI:
1173-2563(2001)21:8<545:EOAOGI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; REPERFUSION THERAPY; TRIAL; ANGIOPLASTY; INHIBITION; MANAGEMENT; PLATELETS; THROMBUS; INSIGHTS; BLOCKADE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Di Pasquale, P Div Cardiol Paolo Borsellino, Via Val Platani 3, I-90144 Palermo, Italy Div Cardiol Paolo Borsellino Via Val Platani 3 Palermo Italy I-90144
Citazione:
P. Di Pasquale et al., "Effects of administration of glycoprotein IIb/IIIa receptor antagonists inpatients with failed thrombolysis - A pilot study", CLIN DRUG I, 21(8), 2001, pp. 545-553

Abstract

Aim: To evaluate the effectiveness of glycoprotein (GP) IIb/IIIa receptor antagonists in patients with acute myocardial infarction (AMI) who have undergone unsuccessful thrombolysis. Design: Randomised, prospective, single-blind trial. Patients and Participants: 84 patients (62 males, 22 females, aged 40 to 80 years) in whom thrombolysis had failed out of a total of 225 consecutive patients admitted to hospital with suspected AMI. Methods: In suitable patients, thrombolysis with 'accelerated' recombinanttissue-type plasminogen activator (rtPA) was initiated. Patients in whom thrombolysis was unsuccessful were randomised within 4 hours of onset of symptoms into two groups, Unsuccessful thrombolysis was defined as failure to show any sign of reperfusion after administration of the first 65mg of rtPA, or as recurrence of pain and ST-segment elevation within 30 to 60 minutesof the end of full thrombolysis (100mg of rtPA). The 42 patients in group 1 (GPIIb/IIIa) stopped thrombolysis (if still being administered) and received treatment with an intravenous bolus plus infusion of GPIIb/IIIa antagonists (abciximab or tirofiban or eptifibatide) plus heparin according to theThrombolysis in Myocardial Infarction (TIMI)- 14 schedule and aspirin. The42 patients in group 2 (placebo) received the full dose of rtPA, even if there was no sign of reperfusion, and placebo together with standard heparinand aspirin. Patients without signs of reperfusion were immediately referred for rescue revascularisation. Results: In group I (GPIIb/IIIa), 22 patients received rtPA 65mg and 20 patients received rtPA 100mg. 39 patients showed rapid reperfusion (4 +/- 3 min) on treatment with GPIIb/IIIa antagonists, and only one required rescue percutaneous transluminal coronary angioplasty (PTCA). Coronarography after12 to 72 hours demonstrated patency of the infarct-related artery in the 39 patients who showed rapid reperfusion. In group 2 (placebo), no patients showed reperfusion and all received rescue PTCA. Three patients in the GPIIb/IIIa group and two in the placebo group experienced bleeding-related adverse effects. Patients receiving GPIIb/IIIa antagonists showed a nonsignificantly reduced requirement for stent treatment and a reduction of angina at 30 days after treatment compared with the placebo group. Conclusion: These preliminary data suggest the possibility of using GPIIb/IIIa receptor antagonists in patients with failed thrombolysis after AMI, with an acceptable increase in bleeding risk. We consider the demonstration of the safety of this combination as the most important result of this study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:21:10