Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
POTENTIAL EFFECT OF CYCLOSPORINE-A IN FORMATION OF CHOLESTEROL GALLSTONES IN PEDIATRIC LIVER-TRANSPLANT RECIPIENTS
Autore:
CAO S; COX K; SO SSK; BERQUIST W; LEE SP; HAIGH WG; CONCEPCION W; MONGE H; ESQUIVEL CO;
Indirizzi:
STANFORD UNIV,MED CTR,DEPT SURG,750 WELCH RD,SUITE 116 PALO ALTO CA 94304 STANFORD UNIV,MED CTR,DEPT SURG PALO ALTO CA 94304 STANFORD UNIV,MED CTR,DEPT PEDIAT PALO ALTO CA 94304 STANFORD UNIV,MED CTR,DEPT GASTROENTEROL PALO ALTO CA 94304 VET AFFAIRS MED CTR,DIV GASTROENTEROL SEATTLE WA 98108
Titolo Testata:
Digestive diseases and sciences
fascicolo: 7, volume: 42, anno: 1997,
pagine: 1409 - 1415
SICI:
0163-2116(1997)42:7<1409:PEOCIF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHENODEOXYCHOLIC ACID; BILE; INHIBITION; CHOLESTASIS; QUANTITATION; FK506; FLOW; HPLC; DRUG; RAT;
Keywords:
GALLSTONES; ORTHOTOPIC LIVER TRANSPLANT; CYCLOSPORINE A; FK506; URSODIOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
S. Cao et al., "POTENTIAL EFFECT OF CYCLOSPORINE-A IN FORMATION OF CHOLESTEROL GALLSTONES IN PEDIATRIC LIVER-TRANSPLANT RECIPIENTS", Digestive diseases and sciences, 42(7), 1997, pp. 1409-1415

Abstract

Recent advancements in Liver transplantation have resulted in extended survival both for grafts and recipients. Such improvement, together with the shortage of donor organs has prompted expansion of the donor pool to include less than ideal donors, especially in life-threateningsituations. The use of older fiver donors has been associated with lower long-term survival. However, potential morbidity such as gallstoneformation has not been explored. We analyzed bile composition in a child who developed cholesterol gallstones in the proximal bile duct twoyears after undergoing emergency liver transplantation with a liver from a 78-year-old donor. Oral administration of ursodeoxycholic acid (ursodiol) shifted the cholesterol composition of the bile from a supersaturated, potentially crystallized state to a liquid (micellar) state. Unlike cyclosporin A, FK506 showed an increase in the proportion of chenodeoxycholic acid and a decrease in the proportion of cholic acid,and thus may exhibit minimal or no hepatotoxic effect. Thus, in donorlivers with factors known to be associated with cholesterol gallstoneformation (such as age, sex, or obesity), one may consider analyzing the bile composition at the time of procurement. Depending on cholesterol and bile acid composition, the use of FK506 with or without addition of ursodeoxycholic acid may be warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:47:43