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Titolo:
Contrasting patterns of streptococcal superantigen-induced T-cell proliferation in guttate vs. chronic plaque psoriasis
Autore:
Davison, SC; Allen, MH; Mallon, E; Barker, JNWN;
Indirizzi:
Univ London Kings Coll, St Johns Inst Dermatol, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England Chelsea & Westminster Hosp, Dept Dermatol, London, England Chelsea & Westminster Hosp London England ept Dermatol, London, England
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 2, volume: 145, anno: 2001,
pagine: 245 - 251
SICI:
0007-0963(200108)145:2<245:CPOSST>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAPHYLOCOCCAL-ENTEROTOXIN-B; BACTERIAL SUPERANTIGENS; LYMPHOCYTES; RECEPTOR; SKIN; STIMULATION; EXPRESSION; INDUCTION; ANTIGEN; LESIONS;
Keywords:
cutaneous lymphocyte associated antigen (CLA); psoriasis; superantigen; V beta T-cell receptor chain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Davison, SC St Marys Hosp, Dept Dermatol, Praed St, London W2 1NY, EnglandSt Marys Hosp Praed St London England W2 1NY W2 1NY, England
Citazione:
S.C. Davison et al., "Contrasting patterns of streptococcal superantigen-induced T-cell proliferation in guttate vs. chronic plaque psoriasis", BR J DERM, 145(2), 2001, pp. 245-251

Abstract

Background Streptococcal infection is strongly associated with guttate psoriasis (GP) and may also exacerbate chronic plaque psoriasis (CPP), possibly through the release of superantigenic toxins. Objectives To investigate superantigen-induced generation of cutaneous lymphocyte associated antigen (CLA) -positive lymphocytes in GP compared with CPRObjectives To investigate superantigen-induced generation of cutaneous lymphocyte associated antigen (CLA) -positive lymphocytes in GP compared with CPRMethods Peripheral blood lymphocyte (PBL) expression of CLA and T-cell receptor VP chain was assessed in patients with CPP and with active and resolved GP. Expression of superantigen-reactive VP families was compared with invitro superantigen-induced peripheral blood mononuclear cell (PBMC) proliferation. Results Peripheral blood mononuclear cells from patients with active GP showed a twofold increased proliferation after stimulation with streptococcalpyogenic toxins A and streptococcal pyogenic toxins C compared with controls (P < 0.01), whereas the response to the staphylococcal toxins and mitogenic stimulation was the same in all groups. Peripheral blood lymphocytes (PBL) from patients with active GP showed increased use of the superantigen-reactive families V beta2 (P < 0.01) and V<beta>17 (P < 0.05), which was notevident in the other patient groups or controls. This pattern of VP expression was only observed in CLA-positive T cells. Furthermore, there was a positive correlation between V<beta>2 expression and enhanced proliferation after stimulation with SPEA (r = 0.82, P < 0.01) and SPEC (r = 0.74, P < 0.05) in active GP. Conclusions This study supports the concept that streptococcal infection precipitates acute GP at least in part through superantigen driven generation of Vp-restricted CLA-positive skin homing lymphocytes, whereas we could find no evidence for a similar mechanism occurring in the maintenance of stable CPP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:01:40