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Titolo:
Effects of small doses of ouabain on the arterial blood pressure of anesthetized hypertensive and normotensive rats
Autore:
Rossoni, LV; Pinto, VD; Vassallo, DV;
Indirizzi:
UFES, CBM, Dept Ciencias Fisiol, BR-29040095 Vitoria, ES, Brazil UFES Vitoria ES Brazil BR-29040095 BCiol, BR-29040095 Vitoria, ES, Brazil
Titolo Testata:
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
fascicolo: 8, volume: 34, anno: 2001,
pagine: 1065 - 1077
SICI:
0100-879X(200108)34:8<1065:EOSDOO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR REACTIVITY; ENDOGENOUS OUABAIN; SALT HYPERTENSION; K+-ATPASE; NA+,K+-ATPASE; EXPRESSION; ISOFORM; NA+; BARORECEPTOR; HYPERTROPHY;
Keywords:
pressor reactivity; ouabain; phenylephrine; 1K1C rats; DOCA-salt; uninephrectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Vassallo, DV UFES, CBM, Dept Ciencias Fisiol, Av Marechal Campus,1468, BR-29040095 Vitoria, ES, Brazil UFES Av Marechal Campus,1468 Vitoria ES BrazilBR-29040095 BC
Citazione:
L.V. Rossoni et al., "Effects of small doses of ouabain on the arterial blood pressure of anesthetized hypertensive and normotensive rats", BRAZ J MED, 34(8), 2001, pp. 1065-1077

Abstract

Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The effects of 0.18 and IS mug/kg, and 1.8 mg/ kg ouabain pretreatment on the phenylephrine (PHE; 0.1, 0.25 and 0.5 pg, in bolus)-evoked pressor responses were investigated using anesthetized normotensive (control and uninephrectomized) and hypertensive (1K1C and DOCA-salt treated) rats. Treatment with 18 mug/kg ouabain increased systolic and diastolic blood pressure in all groups studied. However, the magnitude of this increase was larger for the hypertensive 1K1C and DOCA-salt rats than for normotensive animals, while the pressor effect of 0. 18 mug/kg ouabain was greateronly in DOCA-salt rats. A very large dose (1.8 mg/kg) produced toxic effects on the normotensive control but not on uninephrectomized. or 1K1C rats. Rat tail vascular beds were perfused to analyze the effects of 10 nM ouabain on the pressor response to PHE. In all animals, 10 nM ouabain increased the PHE pressor response, but this increase was larger in hypertensive DOCA-salt rats than in normotensive and 1K1C rats. Results suggested that a) increases in diastolic blood pressure induced by 18 mug/kg ouabain were largerin hypertensive than normotensive rats; b) in DOCA-salt rats, smaller ouabain doses had a stronger effect than in other groups; c) hypertensive and uninephrectomized rats were less sensitive to toxic doses of ouabain, and d)after treatment with 10 nM ouabain isolated tail vascular beds from DOCA-salt rats were more sensitive to the pressor effect of PRE than those from normotensive and 1K1C hypertensive rats. These data suggest that very small doses of ouabain, which might produce nanomolar plasma concentrations, enhance pressor reactivity in DOCA-salt hypertensive rats, supporting the idea that endogenous ouabain may contribute to the increase and maintenance of vascular tone in hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:55:09