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Titolo:
Microinjection of carbachol in the lateral hypothalamus produces opposing actions on nociception mediated by alpha(1)- and alpha(2)-adrenoceptors
Autore:
Holden, JE; Naleway, E;
Indirizzi:
Univ Illinois, Dept Med Surg Nursing, Chicago, IL 60612 USA Univ IllinoisChicago IL USA 60612 ed Surg Nursing, Chicago, IL 60612 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 911, anno: 2001,
pagine: 27 - 36
SICI:
0006-8993(20010817)911:1<27:MOCITL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOLAMINE CELL GROUP; NUCLEUS RAPHE MAGNUS; STIMULATION-PRODUCED ANTINOCICEPTION; PERIAQUEDUCTAL GRAY; SPINAL-CORD; INTRATHECAL INJECTION; NORADRENERGIC NEURONS; RAT; MORPHINE; ANTAGONISTS;
Keywords:
antinociception; alpha(2)-adrenoceptor antagonist; alpha(1)-adrenoceptor antagonist; yohimbine; WB4101; naltrexone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Holden, JE Univ Illinois, Dept Med Surg Nursing, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 sing, Chicago, IL 60612 USA
Citazione:
J.E. Holden e E. Naleway, "Microinjection of carbachol in the lateral hypothalamus produces opposing actions on nociception mediated by alpha(1)- and alpha(2)-adrenoceptors", BRAIN RES, 911(1), 2001, pp. 27-36

Abstract

Electrical stimulation of the lateral hypothalamus (LH) produces antinociception partially blocked by intrathecal alpha -adrenergic. antagonists, butthe mechanism underlying this effect is not clear. Evidence from immunological studies demonstrates that substance P-immunoreactive neurons in the LHproject near the A7 catecholamine cell group, a group of noradrenergic. neurons in the pons. known to effect antinociception in the spinal cord dorsal hom. Such evidence suggests that LH neurons may activate A7 neurons to produce antinociception. To test this hypothesis, the cholinergic agonist carbachol was microinjected into the LH at doses of 63, 125 and 250 nmol and the resulting effects on tail-flick and nociceptive foot-withdrawal latencies were measured. All three doses significantly increased response latencieson both tests, with the 125-nmol dose providing the optimal effect. Intrathecal injection of the opioid antagonist naltrexone (97 nmol) partially reversed antinociception, but neither the alpha (2)-adrenoceptor antagonist yohimbine nor the alpha (1)-adrenoceptor antagonist WB4101 altered latencies. However, two sequential doses of yohimbine blocked LH-induced antinociception on both tests. In contrast, two sequential doses of WB4101 increased nociceptive responses on both the tail-flick and foot-withdrawal tests. Thesefindings, and those of published reports, suggest that neurons in the LH activate spinally projecting methionine enkephalin neurons, as well as two populations of A7 noradrenergic neurons that exert a bidirectional effect onnociception. One of these populations increases nociception through the action of alpha (1)-adrenoceptors and the other inhibits nociception through the action of alpha (2)-adrenoceptors in the spinal cord dorsal horn. (C) 2001 Elsevier Science BY All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:11:17