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Titolo:
Response dynamics of entorhinal cortex in awake, anesthetized, and bulbotomized rats
Autore:
Ahrens, KF; Freeman, WJ;
Indirizzi:
Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t Phys, La Jolla, CA 92093 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 911, anno: 2001,
pagine: 193 - 202
SICI:
0006-8993(20010824)911:2<193:RDOECI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOURCE-DENSITY ANALYSIS; HIPPOCAMPAL THETA-RHYTHM; OLFACTORY SYSTEM; LAYER-II; IN-VIVO; CAT; STIMULATION; POTENTIALS; CELLS; EEG;
Keywords:
oscillation; nonlinear dynamics; olfactory system; local field potential; current source density;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ahrens, KF Univ Calif San Diego, Dept Phys, 7108 Urey Hall,M-C 0319,9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 7108 Urey Hall,M-C 0319,9500 Gilman Dr La Jolla CA USA 92093
Citazione:
K.F. Ahrens e W.J. Freeman, "Response dynamics of entorhinal cortex in awake, anesthetized, and bulbotomized rats", BRAIN RES, 911(2), 2001, pp. 193-202

Abstract

The generation of oscillatory activity may be crucial to brain function. The coordination of individual neurons into rhythmic and coherently active populations is thought to result from interactions between excitatory and inhibitory cells mediated by local feedback connections. By using extracellular recording wires and silicon microprobes to measure electrically evoked damped oscillatory responses at the level of neural populations in the entorhinal cortex, and by using current-source density analysis to determine thespatial pattern of evoked responses, we show that the propagation of activity through the cortical circuit and consequent oscillations in the local field potential are dependent upon background neural activity. Pharmacological manipulations as well as surgical disconnection of the olfactory bulb serve to quell the background excitatory input incident to entorhinal cortex,resulting in evoked responses without characteristic oscillations and showing no signs of polysynaptic feedback. Electrical stimulation at 200 Hz applied to the lateral olfactory tract provides a substitute for the normal background activity emanating from the bulb and enables the generation of oscillatory responses once again. We conclude that a non-zero background levelof activity is necessary and sufficient to sustain normal oscillatory responses and polysynaptic transmission through the entorhinal cortex. (C) 2001Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:02:14