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Titolo:
Role of 5-HT2 receptor subtypes in depletion of 5-HT induced by p-chloroamphetamine in the mouse frontal cortex
Autore:
Yamada, J; Sugimoto, Y; Ohkura, M; Inoue, K; Shinozuka, K; Kunitomo, M;
Indirizzi:
Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Kobe, Hyogo 6588558,Japan Kobe Pharmaceut Univ Kobe Hyogo Japan 6588558 , Kobe, Hyogo 6588558,Japan Mukogawa Womens Univ, Fac Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 663, Japan Mukogawa Womens Univ Nishinomiya Hyogo Japan 663 nomiya, Hyogo 663, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 911, anno: 2001,
pagine: 141 - 145
SICI:
0006-8993(20010824)911:2<141:RO5RSI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; DOPAMINE RELEASE; METHAMPHETAMINE; HYPERTHERMIA; SEROTONIN; NEUROTOXICITY; FENFLURAMINE; TEMPERATURE; DIZOCILPINE;
Keywords:
p-chloroamphetamine; hyperthermia; neurotoxicity; 5-HT2A receptor; 5-HT2B/2C receptor; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, J Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Motoyamakita Machi, Kobe, Hyogo 6588558, Japan Kobe Pharmaceut Univ Motoyamakita Machi Kobe Hyogo Japan 6588558
Citazione:
J. Yamada et al., "Role of 5-HT2 receptor subtypes in depletion of 5-HT induced by p-chloroamphetamine in the mouse frontal cortex", BRAIN RES, 911(2), 2001, pp. 141-145

Abstract

A serotonin (5-hydroxytryptamine, 5-HT)-releasing drug, p-chloroamphetamine elicited decreases in 5-HT levels in the mouse frontal cortex. 5-HT reduction elicited by p-chloroamphetamine was inhibited by the 5-HT2A/2B/2C receptor antagonist, LY 53857 and the 5-HT2A receptor antagonist, ketanserin. However, the 5-HT2B/2C receptor antagonist, SB 206553, enhanced it. LY 53857and ketanserin can inhibit hyperthermia elicited by p-chloroamphetamine, although SB 206553 enhances it. The effects of the 5-HT2 receptor antagonists on neurotoxicity are very similar to those on hyperthermia. Since hyperthermia facilitates neurotoxicity induced by amphetamine analogue, these 5-HT2 receptor antagonists may modify 5-HT depletion induced by p-chloroamphetamine through responses to body temperature. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:48:59