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Titolo:
Monitoring clinical trials with multiple arms
Autore:
Hellmich, M;
Indirizzi:
Univ Cologne, Dept Med Stat Informat & Epidemiol, D-50924 Cologne, GermanyUniv Cologne Cologne Germany D-50924 Epidemiol, D-50924 Cologne, Germany
Titolo Testata:
BIOMETRICS
fascicolo: 3, volume: 57, anno: 2001,
pagine: 892 - 898
SICI:
0006-341X(200109)57:3<892:MCTWMA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADAPTIVE INTERIM ANALYSES; PAIRWISE COMPARISONS; END-POINTS; DESIGN;
Keywords:
adaptive interim analysis; closed testing; group sequential trials; multiple testing; multiple treatments;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hellmich, M Univ Cologne, Dept Med Stat Informat & Epidemiol, Joseph Stelzmann Str 9, D-50924 Cologne, Germany Univ Cologne Joseph Stelzmann Str 9 Cologne Germany D-50924 y
Citazione:
M. Hellmich, "Monitoring clinical trials with multiple arms", BIOMETRICS, 57(3), 2001, pp. 892-898

Abstract

In order to benefit from the substantial overhead expenses of a large group sequential clinical trial, the simultaneous investigation of several competing treatments becomes more popular. If at some interim analysis any treatment arm reveals itself to be inferior to any other treatment under investigation, this inferior arm may be or may even need to be dropped for ethical and/or economic reasons. Recently proposed methods for monitoring and analysis of group sequential clinical trials with multiple treatment arms are compared and discussed. The main focus of the article is on the applicationand extension of (adaptive) closed testing procedures in the group sequential setting that strongly control the familywise error rate. A numerical example is given for illustration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:38:58