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Titolo:
Factors affecting fluvoxamine antidepressant activity: Influence of pindolol and 5-HTTLPR in delusional and nondelusional depression
Autore:
Zanardi, R; Serretti, A; Rossini, D; Franchini, L; Cusin, C; Lattuada, E; Dotoli, D; Smeraldi, E;
Indirizzi:
Vita Salute Univ, San Raffaele Inst, Dept Psychiat, Milan, Italy Vita Salute Univ Milan Italy Raffaele Inst, Dept Psychiat, Milan, Italy
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 5, volume: 50, anno: 2001,
pagine: 323 - 330
SICI:
0006-3223(20010901)50:5<323:FAFAAI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER GENE; BIPOLAR AFFECTIVE-DISORDER; PLACEBO-CONTROLLED TRIAL; RESPONSIVE AFFECTIVE-DISORDERS; COLLABORATIVE RESEARCH-PROGRAM; MAJOR DEPRESSION; FUNCTIONAL POLYMORPHISM; NONPSYCHOTIC DEPRESSION; PSYCHOTIC DEPRESSION; DOUBLE-BLIND;
Keywords:
serotonin transporter; pindolol; fluvoxamine; depression; treatment response; pharmacogenetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Zanardi, R Univ Milan, Osped San Raffaele, Sch Med, Inst Sci, Via Prinetti29, I-20127 Milan, Italy Univ Milan Via Prinetti 29 Milan Italy I-20127 27 Milan, Italy
Citazione:
R. Zanardi et al., "Factors affecting fluvoxamine antidepressant activity: Influence of pindolol and 5-HTTLPR in delusional and nondelusional depression", BIOL PSYCHI, 50(5), 2001, pp. 323-330

Abstract

Background: It has been recently reported that the short variant of the serotonin transporter (5-HTT) gene-linked functional polymorphic region (5-HTTLPR) influences the antidepressant response to certain selective serotoninreuptake inhibitors. The aim of the present study was to test this findingin a sample of major and bipolar depressives, with or without psychotic features. Methods: One hundred fifty-five inpatients were treated with fluvoxamine 300 mg and either placebo or pindolol in a double-blind design for 6 weeks. The severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression. Allelic variation of 5-HTTLPR in each subject was determined using a polymerase chain reaction-based technique. Results: 5-HTTLPR short variant was associated with a poor response to fluvoxamine treatment, independently from the recorded clinical variables. More specifically, the diagnosis, the presence of psychotic features, and the severity of depressive symptomatology did not influence this association. Conversely, pindolol augmentation may ameliorate the rate of response in 5-HTTLPR short van. ant subjects, thus reducing the difference in the responserate among the genotype variants. Conclusions: If confirmed, these results may improve patient care by helping the clinician to individualize treatment according to the patient's genetic 5-HTTLPR pattern. Biol Psychiatry 2001;50:323-330 (C) 2001 Society of Biological Psychiatry.

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Documento generato il 04/04/20 alle ore 01:24:51