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Titolo:
Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside
Autore:
Miura, T; Ichiki, H; Iwamoto, N; Kato, M; Kubo, M; Sasaki, H; Okada, M; Ishida, T; Seino, Y; Tanigawa, K;
Indirizzi:
Suzuka Unvi Med Sci, Dept Clin Nutr, Suzuka, Mie 5100293, Japan Suzuka Unvi Med Sci Suzuka Mie Japan 5100293 , Suzuka, Mie 5100293, Japan Kyoto Univ, Sch Med, Dept Metab & Clin Nutr, Sakyo Ku, Kyoto 6060123, Japan Kyoto Univ Kyoto Japan 6060123 Clin Nutr, Sakyo Ku, Kyoto 6060123, Japan Tsumura & Co, Tsumura Cent Res Labs, Amimachi, Ibaraki 30011, Japan Tsumura & Co Amimachi Ibaraki Japan 30011 Amimachi, Ibaraki 30011, Japan Suzuka Univ Med Sci, Hitech Res Ctr, Suzuka, Mie 5100293, Japan Suzuka Univ Med Sci Suzuka Mie Japan 5100293 , Suzuka, Mie 5100293, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 9, volume: 24, anno: 2001,
pagine: 1009 - 1011
SICI:
0918-6158(200109)24:9<1009:AAOTRO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETIC MICE;
Keywords:
Anemarrhena asphodeloides; mangiferin; antidiabetic activity; KK-Ay mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Miura, T Suzuka Unvi Med Sci, Dept Clin Nutr, 1001-1 Kishioka, Suzuka, Mie5100293,Japan Suzuka Unvi Med Sci 1001-1 Kishioka Suzuka Mie Japan 5100293apan
Citazione:
T. Miura et al., "Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside", BIOL PHAR B, 24(9), 2001, pp. 1009-1011

Abstract

The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. Thewater extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570 +/- 29 to 401 +/- 59 mg/dl 7 h after oral administration (p <0.05)and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may bedue to decreased insulin resistance. In addition, the active components ofAA were confirmed to be mangiferin and its glucoside.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:00:36