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Titolo:
Enhancement of immobility induced by repeated phencyclidine injection: association with c-Fos protein in the mouse brain
Autore:
Sayed, MAN; Noda, Y; Hamdy, MM; Mamiya, T; Nagai, T; Furukawa, H; Nabeshima, T;
Indirizzi:
Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Showa Ku, Nagoya, Aichi 4668650, Japan Nagoya Univ Nagoya Aichi Japan 4668650 a Ku, Nagoya, Aichi 4668650, Japan Assiut Univ, Grad Sch Med, Dept Pharmacol, Assiut 71516, Egypt Assiut Univ Assiut Egypt 71516 Med, Dept Pharmacol, Assiut 71516, Egypt Meijo Univ, Fac Pharmaceut Sci, Dept Med Chem, Nagoya, Aichi 4668503, Japan Meijo Univ Nagoya Aichi Japan 4668503 Chem, Nagoya, Aichi 4668503, Japan
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 124, anno: 2001,
pagine: 71 - 76
SICI:
0166-4328(20010928)124:1<71:EOIIBR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORCED SWIMMING TEST; IMMEDIATE-EARLY GENES; EXPRESSION; RAT; SCHIZOPHRENIA; NEURONS; CORTEX; NMDA; NEUROTRANSMISSION; KETAMINE;
Keywords:
phencyclidine; immobility; c-Fos protein expression; negative symptoms of schizophrenia; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Nabeshima, T Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Showa Ku, 65 Tsurumacho, Nagoya, Aichi 4668650, Japan Nagoya Univ 65 Tsurumacho Nagoya Aichi Japan 4668650 0, Japan
Citazione:
M.A.N. Sayed et al., "Enhancement of immobility induced by repeated phencyclidine injection: association with c-Fos protein in the mouse brain", BEH BRA RES, 124(1), 2001, pp. 71-76

Abstract

Immunohistochemistry of c-Fos protein was performed to study changes in neuronal activity in discrete brain areas of mice repeatedly treated with phencyclidine (PCP) showing enhancement of immobility in the forced swimming test, this behavioral change being considered as avolition, which is one of negative symptoms of schizophrenia. Repeated treatment with PCP significantly prolonged immobility time in the forced swimming test, compared with saline treatment. The c-Fos protein expression of mice showing PCP-induced enhancement of immobility was increased in certain brain regions, such as the retrosplenial cortex, pyriform. cortices, pontine nuclei, cingulate, frontal cortex and thalamus, compared with that of PCP-treated, non-swimming and saline-treated, swimming groups. These results suggest that increased c-Fosprotein is involved in the expression of PCP-induced enhancement of immobility, and c-Fos expression plays a role in negative symptoms-like behavioral changes. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:54:52