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Titolo:
Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus
Autore:
Shaw, KN; Commins, S; OMara, SM;
Indirizzi:
Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 ept Psychol, Dublin 2, Ireland
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 124, anno: 2001,
pagine: 47 - 54
SICI:
0166-4328(20010928)124:1<47:LCDISL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NEUROTROPHIC FACTOR; SYNAPTIC TRANSMISSION; CHRONIC NEUROINFLAMMATION; BEHAVIORAL STRESS; FEBRILE RESPONSE; MEMORY; HIPPOCAMPUS; ENDOTOXIN; INTERLEUKIN-1-BETA;
Keywords:
lipopolysaccharide; BDNF; learning; memory; watermaze; dentate gyrus; LPS tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: O'Mara, SM Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 , Dublin 2, Ireland
Citazione:
K.N. Shaw et al., "Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus", BEH BRA RES, 124(1), 2001, pp. 47-54

Abstract

We investigated the effects of a single injection and a daily injection oflipopolysaccharide (LPS) on spatial learning and brain-derived neurotrophic factor (BDNF) expression in the rat dentate gyrus. LPS is derived from the cell wall of Gram-negative bacteria and is a potent endotoxin that causesthe release of cytokines such as interleukin-1 and tumour necrosis factor. LPS is thought to activate both the neuroimmune and neuroendocrine systems; it also blocks long-term potentiation in the hippocampus. Here, we examined the effects of LPS on a form of hippocampal-dependent learning-spatial learning in the water maze. Rats were injected with LPS intraperitoneally (100 mug/kg) and trained in the water maze. The first group of rats were injected on day 1 of training, 4 h prior to learning the water maze task. Groups 2 and 3 were injected daily, again 4 h prior to the water-maze task; group 2 with LPS and group 3 with saline. A number of behavioural variables were recorded by a computerised tracking system for each trial. The behavioural. results showed a single injection of LPS (group 1) impaired escape latency in both the acquisition and retention phases of the study, whereas a daily injection of LPS did not significantly impair acquisition or retention. BDNF expression was analysed in the dentate gyrus of all animals. No significant differences in BDNF expression were found between the three groups. (C) 2001 Elsevier Science BY. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:56:24