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Titolo:
Memory disruption in rats with nigral lesions induced by MPTP: a model forearly Parkinson's disease amnesia
Autore:
Da Cunha, C; Gevaerd, MS; Vital, MABF; Miyoshi, E; Andreatini, R; Silveira, R; Takahashi, RN; Canteras, NS;
Indirizzi:
UFPR, Dept Farmacol, Lab Fisiol & Farmacol, SNC, BR-81531990 Curitiba, Parana, Brazil UFPR Curitiba Parana Brazil BR-81531990 BC531990 Curitiba, Parana, Brazil UFSC, Dept Farmacol, Florianopolis, SC, Brazil UFSC Florianopolis SC Brazil C, Dept Farmacol, Florianopolis, SC, Brazil USP, Fac Filosofia Ciencias & Letras, Dept Psicobiol, Ribeirao Preto, Brazil USP Ribeirao Preto Brazil etras, Dept Psicobiol, Ribeirao Preto, Brazil USP, Inst Ciencias Biomed 1, Dept Fisiol & Biofis, Sao Paulo, Brazil USP Sao Paulo Brazil Biomed 1, Dept Fisiol & Biofis, Sao Paulo, Brazil
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 124, anno: 2001,
pagine: 9 - 18
SICI:
0166-4328(20010928)124:1<9:MDIRWN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIA; PROCEDURAL MEMORY; ACTIVE-AVOIDANCE; CAUDATE-NUCLEUS; WATER MAZE; 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE MPTP; 6-HYDROXYDOPAMINE LESIONS; COGNITIVE FUNCTIONS; LEARNING-DEFICITS; DOPAMINE NEURONS;
Keywords:
Parkinson's disease; MPTP; memory; striatum; dopamine; animal model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Da Cunha, C UFPR, Dept Farmacol, Lab Fisiol & Farmacol, SNC, CP 19-031, BR-81531990 Curitiba, Parana, Brazil UFPR CP 19-031 Curitiba Parana Brazil BR-81531990 BCna, Brazil
Citazione:
C. Da Cunha et al., "Memory disruption in rats with nigral lesions induced by MPTP: a model forearly Parkinson's disease amnesia", BEH BRA RES, 124(1), 2001, pp. 9-18

Abstract

Intra-nigral administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) caused a lesion in the substantia nigra, compact part (SNc) and aspecific loss of dopamine and its metabolites in the striatum of rats, Theanimals were then tested in the two-way active avoidance task. MPTP-treated animals presented lower learning scores in the training and test sessions, an effect that was not caused by motor impairment or by a decreased sensitivity to footshock since their reaction time to the footshock (unconditioned stimulus - UCS) was not reduced. These lower scores were also not attributable to lower acoustic sensitivity or to a slowing in the association of the sound cue (conditioned stimulus - CS) with the UCS since the reaction time to the CS in the active avoidance response did not differ between MPTP-treated and control groups, Therefore, these results are more properly attributable to an impairment of the memory acquisition and retention processes, In addition, this study is presented as a model of early Parkinson's Disease amnesia and is discussed in terms of the importance of the nigrostriatal pathway to memory acquisition and storage processes, (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/01/20 alle ore 00:33:30