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Titolo:
Genetic variation at the lipoprotein lipase locus and plasma lipoprotein and insulin levels in the Quebec Family Study
Autore:
Ukkola, O; Garenc, C; Perusse, L; Bergeron, J; Despres, JP; Rao, DC; Bouchard, C;
Indirizzi:
Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA Pennington Biomed ResCtr Baton Rouge LA USA 70808 on Rouge, LA 70808 USA Univ Oulu, Dept Internal Med, FIN-90220 Oulu, Finland Univ Oulu Oulu Finland FIN-90220 t Internal Med, FIN-90220 Oulu, Finland Univ Oulu, Bioctr Oulu, FIN-90220 Oulu, Finland Univ Oulu Oulu Finland FIN-90220 u, Bioctr Oulu, FIN-90220 Oulu, Finland Univ Laval, Div Kinesiol, Phys Act Sci Lab, St Foy, PQ G1K 7P4, Canada Univ Laval St Foy PQ Canada G1K 7P4 t Sci Lab, St Foy, PQ G1K 7P4, Canada Univ Laval, Lipid Res Ctr, St Foy, PQ, Canada Univ Laval St Foy PQ Canada niv Laval, Lipid Res Ctr, St Foy, PQ, Canada Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Div Biostat, St Louis, MO 63110 USA
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 158, anno: 2001,
pagine: 199 - 206
SICI:
0021-9150(200109)158:1<199:GVATLL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; ISCHEMIC-HEART-DISEASE; DNA POLYMORPHISMS; MYOCARDIAL-INFARCTION; HDL CHOLESTEROL; LPL GENE; ASSOCIATION; DENSITY; MUTATION; MEN;
Keywords:
lipoprotein lipase; lipids; lipoproteins; genetics; gene polymorphisms; body fat; abdominal fat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Bouchard, C Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA Pennington Biomed Res Ctr 6400 Perkins Rd Baton Rouge LA USA 70808
Citazione:
O. Ukkola et al., "Genetic variation at the lipoprotein lipase locus and plasma lipoprotein and insulin levels in the Quebec Family Study", ATHEROSCLER, 158(1), 2001, pp. 199-206

Abstract

The associations between the S447X, BamHI, HindIII and PvuII DNA variants of the lipoprotein lipase (LPL) gene and indicators of body fat, fat distribution and plasma lipids and insulin were studied in the Quebec Family Study cohort. Strong linkage disequilibrium among all the markers was observed. For the S447X polymorphism, plasma very low density lipoprotein (VLDL)-cholesterol (chol) (P < 0.001), total triglyceride (TG) (P = 0.033) and VLDL-TG (P < 0.001) levels were lower and high density lipoprotein (HDL)-chol level higher (P < 0.001) in the subjects homozygous or heterozygous for X447 (X447 +, n = 160) compared to the homozygotes for the S447 allele (X447 -, n= 576). The BamHI, PvuII and HindIII polymorphisms were not associated with the plasma lipid values when all X447 allele carriers were removed. In addition, the HindIII polymorphism as well as the HindIII and S447X markers combination influenced the insulin area under the curve during an oral glucose tolerance test. We conclude that DNA sequence variation in the LPL gene contributes significantly to the variability in the levels of VLDL-chol, total- and VLDL-TG as well as HDL-chol. The effects of the other polymorphisms considered here are most likely mediated by their linkage disequilibrium with the S447X mutation. In addition, genetic variation at the LPL locus may, by an unknown mechanism, influence insulin metabolism but not body fat variability. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:35:54