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Titolo:
The rise of the plasma lipid concentration elicited by dietary sodium chloride restriction in Wistar rats is due to an impairment of the plasma triacylglycerol removal rate
Autore:
Catanozi, S; Rocha, JC; Nakandakare, ER; Passarelli, M; Mesquita, CH; Silva, AA; Dolnikoff, MS; Harada, LM; Quintao, ECR; Heimann, JC;
Indirizzi:
Univ Sao Paulo, Sch Med, Lipids Lab LIM 10, BR-01246903 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-01246903 BC01246903 Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Expt Hypertens Lab LIM 16, BR-05508 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05508 16, BR-05508 Sao Paulo, Brazil Univ Sao Paulo, Nucl Res Inst, BR-05508 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-05508 nst, BR-05508 Sao Paulo, Brazil
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 158, anno: 2001,
pagine: 81 - 86
SICI:
0021-9150(200109)158:1<81:TROTPL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; LOW-DENSITY LIPOPROTEIN; LOW-SALT DIET; INSULIN-RESISTANCE; BLOOD-PRESSURE; ARTERY DISEASE; FATTY-ACIDS; NORMOTENSIVE ADULTS; SERUM-LIPIDS; HYPERTENSION;
Keywords:
salt restriction; Triton-WR 1339; triacylglycerol synthesis; plasma lipoprotein kinetics; hypertriglyceridemia; hyperlipidemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Quintao, ECR Univ Sao Paulo, Sch Med, Lipids Lab LIM 10, Av Dr Arnaldo 455S-3317, BR-01246903 Sao Paulo, Brazil Univ Sao Paulo Av Dr Arnaldo 455 S-3317 Sao Paulo Brazil BR-01246903 BC
Citazione:
S. Catanozi et al., "The rise of the plasma lipid concentration elicited by dietary sodium chloride restriction in Wistar rats is due to an impairment of the plasma triacylglycerol removal rate", ATHEROSCLER, 158(1), 2001, pp. 81-86

Abstract

Studies in humans have indicated that dietary salt restriction raises plasma levels of total cholesterol (TC) and triacylglycerols (TAG). In order toexplain the mechanisms involved, a rat experimental model was developed consisting of chronic feeding ad libitum isocaloric diets with variable sodium chloride contents. Rates of synthesis of plasma TAG were measured either as the increase of plasma TAG after blocking its removal from plasma by theintra-arterial pulse infusion of Triton-WR 1339, or as the plasma rate of incorporation of [C-14]-oleic acid [C-14]-TAG. Plasma TAG removal rate was determined by the intra-arterial pulse infusion of a lipid emulsion. Severesalt restriction increased the plasma concentrations of TAG (71%) and of TC (10%). This result was not due to modification of the rate of synthesis of plasma TAG but was attributed to a 55% slower rate of removal of the TAG-containing lipoproteins. An increased plasma non-esterified fatty acid concentration, probably due to a salt restriction-related insulin resistance, may have impaired the activity of the enzyme lipoprotein lipase. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:21:26