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Titolo:
HYPOLIPIDEMIC EFFECT OF SAIKO-KA-RYUKOTSU-BOREI-TO (TJ-12) IN PATIENTS WITH TYPE-II OR TYPE-IV HYPERLIPIDEMIA
Autore:
NOMURA K; HAYASHI K; KUGA Y; OKURA Y; TANAKA K; YASUNOBU Y; SHINGU T; OHTANI H; KAJIYAMA G;
Indirizzi:
HIROSHIMA UNIV,SCH MED,DEPT INTERNAL MED 1,MINAMI KU,1-2-3 KASUMI HIROSHIMA 734 JAPAN JR HIROSHIMA HOSP HIROSHIMA JAPAN
Titolo Testata:
Current therapeutic research
fascicolo: 7, volume: 58, anno: 1997,
pagine: 446 - 453
SICI:
0011-393X(1997)58:7<446:HEOS(I>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GINSENG SAPONINS; LOWERING ACTION; CHOLESTEROL; PLASMA;
Keywords:
SAIKO-KA-RYUKOTSU-BOREI-TO (KAMPO MEDICINE); TYPE II OR TYPE IV HYPERLIPIDEMIA; LOW-DENSITY LIPOPROTEIN CHOLESTEROL; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K. Nomura et al., "HYPOLIPIDEMIC EFFECT OF SAIKO-KA-RYUKOTSU-BOREI-TO (TJ-12) IN PATIENTS WITH TYPE-II OR TYPE-IV HYPERLIPIDEMIA", Current therapeutic research, 58(7), 1997, pp. 446-453

Abstract

This open-label, uncontrolled trial evaluated the effect of Kampo medicine, Saiko-ka-ryukotsu-borei-to (TJ-12), on plasma lipids and apolipoproteins in 21 patients (3 men and 18 women) with type II or type TV hyperlipidemia, The mean age of the patients wits 60.2 +/- 7.2 years and the mean weight was 55.9 +/- 9.4 kg. Twelve weeks after daily administration of 7.5 g of TJ-12, total cholesterol levels, low-density Lipoprotein (LDL)-cholesterol levels, and the atherogenic index (defined as the difference between total cholesterol levels and high-density lipoprotein [HDL]-cholesterol levels divided by HDL-cholesterol levels) were significantly decreased (pretreatment vs posttreatment mean value, 263 +/- 31 mg/dL vs 239 +/- 36 mg/dL, 177 +/- 39 mg/dL, vs 163 +/- 35 mg/dL, and 4.3 +/- 8.9 mg/dL vs 3.8 +/- 8.7 mg/dL, respectively), There was a significant positive correlation between the change in totalcholesterol levels and that in LDL-cholesterol levels, These results suggest that TJ-12 might diminish atherogenesis by reducing the plasmalevels of total cholesterol and LDL-cholesterol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:37:26