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Titolo:
Stem cell bioengineering
Autore:
Zandstra, PW; Nagy, A;
Indirizzi:
Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada Univ Toronto Toronto ON Canada M5S 3G9 Engn, Toronto, ON M5S 3G9, Canada Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3G9, Canada UnivToronto Toronto ON Canada M5S 3G9 Chem, Toronto, ON M5S 3G9, Canada Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5S 3G9, Canada Mt Sinai Hosp Toronto ON Canada M5S 3G9 Inst, Toronto, ON M5S 3G9, Canada
Titolo Testata:
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
, volume: 3, anno: 2001,
pagine: 275 - 305
SICI:
1523-9829(2001)3:<275:SCB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN HEMATOPOIETIC-CELLS; HUMAN BONE-MARROW; MOBILIZED PERIPHERAL-BLOOD; ADULT MAMMALIAN FOREBRAIN; COLONY-STIMULATING FACTOR; EPIDERMAL GROWTH-FACTOR; CENTRAL-NERVOUS-SYSTEM; EX-VIVO EXPANSION; IN-VIVO; SELF-RENEWAL;
Keywords:
cellular engineering; tissue engineering; self-renewal and differentiation; bioprocess design; applied developmental biology; microenvironment; embryonic and tissue-specific stem cells;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
177
Recensione:
Indirizzi per estratti:
Indirizzo: Zandstra, PW Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9,Canada Univ Toronto Toronto ON Canada M5S 3G9 o, ON M5S 3G9, Canada
Citazione:
P.W. Zandstra e A. Nagy, "Stem cell bioengineering", ANN REV B E, 3, 2001, pp. 275-305

Abstract

Tissue engineering and cellular therapies, either on their own or in combination with therapeutic gene delivery, have the potential to significantly impact medicine. Implementation of technologies based on these approaches requires a readily available source of cells for the generation of cells andtissues outside a living body. Because of their unique capacity to regenerate functional tissue for the lifetime of an organism, stem cells are an attractive "raw material" for multiple biotechnological applications. By definition they are self-renewing because on cell division they can generate daughter stem cells. They are also multipotent because they can differentiateinto numerous specialized, functional cells. Recent findings have shown that stem cells exist in most, if not all, tissues, and that stem cell tissuespecificity may be more flexible than originally thought. Although the potential for producing novel cell-based products from stem cells is large, currently there are no effective technologically relevant methodologies for culturing stem cells outside the body, or for reproducibly stimulating them to differentiate into functional cells. A mechanistic understanding of the parameters important in the control of stem cell self-renewal and lineage commitment is thus necessary to guide the development of bioprocesses for the ex vivo culture of stem cells and their derivates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:54:27