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Titolo:
Cardiac energy metabolism: Models of cellular respiration
Autore:
Jafri, MS; Dudycha, SJ; ORourke, B;
Indirizzi:
Univ Texas, Dept Math Sci, Richardson, TX 75083 USA Univ Texas RichardsonTX USA 75083 ept Math Sci, Richardson, TX 75083 USA Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 d Engn, Baltimore, MD 21205 USA Johns Hopkins Univ, Inst Mol Cardiobiol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 iobiol, Baltimore, MD 21205 USA
Titolo Testata:
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
, volume: 3, anno: 2001,
pagine: 57 - 81
SICI:
1523-9829(2001)3:<57:CEMMOC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRICARBOXYLIC-ACID CYCLE; PERFUSED RAT-HEART; MITOCHONDRIAL BETA-OXIDATION; SENSITIVE K+ CHANNELS; NADH SHUTTLE SYSTEM; DICTYOSTELIUM-DISCOIDEUM; ATP SYNTHESIS; DEHYDROGENASE COMPLEX; INSULIN-SECRETION; CITRATE SYNTHASE;
Keywords:
glycolysis; oxidative phosphorylation; tricarboxylic acid cycle; electron transport; computer model;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Jafri, MS Univ Texas, Dept Math Sci, Richardson, TX 75083 USA Univ Texas Richardson TX USA 75083 ci, Richardson, TX 75083 USA
Citazione:
M.S. Jafri et al., "Cardiac energy metabolism: Models of cellular respiration", ANN REV B E, 3, 2001, pp. 57-81

Abstract

The heart requires a large amount of energy to sustain both ionic homeostasis and contraction. Under normal conditions, adenosine triphosphate (ATP) production meets this demand. Hence, there is a complex regulatory system that adjusts energy production to meet this demand. However, the mechanisms for this control are a topic of active debate. Energy metabolism can be divided into three main stages: substrate delivery to the tricarboxylic acid (TCA) cycle, the TCA cycle, and oxidative phosphorylation. Each of these processes has multiple control points and exerts control over the other stages. This review discusses the basic stages of energy metabolism, mechanisms of control, and the mathematical and computational models that have been used to study these mechanisms.

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Documento generato il 01/04/20 alle ore 23:55:53