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Titolo:
Bradykinin elicits "second window" myocardial protection in rat heart through an NO-dependent mechanism
Autore:
Ebrahim, Z; Yellon, DM; Baxter, GF;
Indirizzi:
Univ Coll London, Hatter Inst, London WC1E 6DB, England Univ Coll London London England WC1E 6DB Inst, London WC1E 6DB, England
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: H1458 - H1464
SICI:
0363-6135(200109)281:3<H1458:BE"WMP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARGININE METHYL-ESTER; A(1) RECEPTOR ACTIVATION; MONOPHOSPHORYL LIPID-A; NITRIC-OXIDE; ADENOSINE RECEPTOR; CONSCIOUS RABBITS; BRIEF ISCHEMIA; LATE-PHASE; INVOLVEMENT; INFARCTION;
Keywords:
infarct size; nitric oxide synthase; preconditioning;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Baxter, GF Univ Coll London Hosp, Hatter Inst, Grafton Way, London WC1E 6DB, England Univ Coll London Hosp Grafton Way London England WC1E 6DB land
Citazione:
Z. Ebrahim et al., "Bradykinin elicits "second window" myocardial protection in rat heart through an NO-dependent mechanism", AM J P-HEAR, 281(3), 2001, pp. H1458-H1464

Abstract

Bradykinin is an important endogenous mediator exerting acute protective effects in the ischemic myocardium. The aims of this study were to investigate whether exogenously administered bradykinin could evoke delayed myocardial protection and to determine whether any protection observed might be dependent on nitric oxide (NO) generation. Conscious rats received bradykinin (40 mug/kg iv) or saline preceded 15-20 min earlier by the NO synthase inhibitor N-w-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg ip) or saline. Twenty-four hours later, hearts were Langendorff perfused and subjected to 35min of regional ischemia. and 120 min of reperfusion. Infaret size was assessed using tetrazolium staining and expressed as a percentage of the risk zone. Bradykinin pretreatment reduced the infarct-to-risk ratio from 53.5 +/- 3.2% to 29.1 +/- 4.7% (P < 0.01). The administration Of L-NAME before bradykinin abrogated the delayed protection (infarct size 52.3 +/- 5.0%) but alone did not influence infarct size (53.5 +/- 4.8%). These results are thefirst to demonstrate that bradykinin can evoke a delayed ("second window")enhancement of myocardial tolerance to ischemia, an action that is dependent on the early generation of NO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 02:55:44