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Titolo:
MR imaging measurement of compartmental water diffusion in perfused heart slices
Autore:
Forder, JR; Bui, JD; Buckley, DL; Blackband, SJ;
Indirizzi:
Univ Alabama, Ctr NMR Res & Dev, Dept Med, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 , Dept Med, Birmingham, AL 35294 USA Univ Alabama, Dept Biomed Engn, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 iomed Engn, Birmingham, AL 35294 USA Univ Florida, Inst Brain, Dept Neurosci, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Neurosci, Gainesville, FL 32611 USA Univ Florida, Inst Brain, Dept Physiol, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Physiol, Gainesville, FL 32611 USA Natl High Magnet Field Lab, Tallahassee, FL 32310 USA Natl High Magnet Field Lab Tallahassee FL USA 32310 ahassee, FL 32310 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: H1280 - H1285
SICI:
0363-6135(200109)281:3<H1280:MIMOCW>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; MAGNETIC-RESONANCE; HIPPOCAMPAL SLICE; DIABETIC RATS; IN-VIVO; MYOCYTES; TISSUE; ANISOTROPY; BRAIN;
Keywords:
heart; diffusion; nuclear magnetic resonance; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Forder, JR Univ Alabama, Ctr NMR Res & Dev, Dept Med, 828 8th Ct S, Birmingham, AL 35294 USA Univ Alabama 828 8th Ct S Birmingham AL USA 35294 AL 35294 USA
Citazione:
J.R. Forder et al., "MR imaging measurement of compartmental water diffusion in perfused heart slices", AM J P-HEAR, 281(3), 2001, pp. H1280-H1285

Abstract

Myocardial tissue slices were isolated from the left ventricular free wall(7 slices) and left ventricular papillary muscle (3 slices) of New ZealandWhite male rabbits (n = 4) and were subsequently superfused with a modified St. Thomas' Hospital cardioplegic solution at 19 degreesC. The diffusion-weighted images were obtained with a 600-MHz nuclear magnetic resonance spectrometer using diffusion gradient b-values that ranged from 166 to 6.408 s/mm(2); the apparent diffusion coefficient of water in the tissues were subsequently calculated. All of the tissue samples that were studied exhibitednonmonoexponential diffusion. Data from seven slices were mathematically fitted by a biexponential expression with a fast diffusion component of 0.72+/- 0.07 x 10(-3) MM2/s, and a slow diffusion component of 0.060 +/- 0.033X 10(-3) mm(2)/s. The fast component dominated the calculated apparent diffusion coefficient of the tissue, composed of 82 +/- 3% of the overall diffusion-dependent signal decay. Thus myocardial tissue exhibits characteristics consistent with multiple compartments of diffusion. This work has important implications for myocardial diffusion tensor imaging, as well as the changes in diffusion that have been reported following myocardial ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:36:36