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Titolo:
ANG II in median preoptic nucleus and pressor responses to CSF sodium and high sodium intake in SHR
Autore:
Budzikowski, AS; Leenen, FHH;
Indirizzi:
Univ Ottawa, Inst Heart, Hypertens Unit, Ottawa, ON K1Y 4W7, Canada Univ Ottawa Ottawa ON Canada K1Y 4W7 ens Unit, Ottawa, ON K1Y 4W7, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: H1210 - H1216
SICI:
0363-6135(200109)281:3<H1210:AIIMPN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; OUABAIN-LIKE ACTIVITY; BLOOD-PRESSURE; ANGIOTENSIN-II; BRAIN OUABAIN; SENSITIVE HYPERTENSION; SUBFORNICAL ORGAN; CONSCIOUS RATS; RECEPTORS; NEURONS;
Keywords:
ouabain; sympathetic activity; guanabenz; losartan; renin-angiotensin system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Leenen, FHH Univ Ottawa, Inst Heart, Hypertens Unit, 40 Ruskin St, Ottawa,ON K1Y 4W7,Canada Univ Ottawa 40 Ruskin St Ottawa ON Canada K1Y 4W7 Y 4W7,Canada
Citazione:
A.S. Budzikowski e F.H.H. Leenen, "ANG II in median preoptic nucleus and pressor responses to CSF sodium and high sodium intake in SHR", AM J P-HEAR, 281(3), 2001, pp. H1210-H1216

Abstract

Pressor responses to increases in cerebrospinal fluid (CSF) sodium in Wistar rats and to high salt intake in spontaneously hypertensive rats (SHR) involve both brain ouabainlike activity ("ouabain") and the brain renin-angiotensin system (RAS). Because some of the effects of "ouabain" are mediated by the median preoptic nucleus (MnPO) and this nucleus contains all elements of the RAS, the present study assessed possible interactions of "ouabain"and ANG II in this nucleus. In conscious Wistar rats, injection of ANG II into the MnPO significantly increased mean arterial pressure (MAP) and heart rate (HR). This response was not affected by pretreatment with a subpressor dose of ouabain. MAP and HR increases by ouabain in the MnPO were significantly attenuated by MnPO pretreatment with losartan. In Wistar rats losartan in the MnPO also abolished pressor and HR responses to intracerebroventricular 0.3 M NaCl and attenuated MAP and HR responses to intracerebroventricular ouabain. Five weeks of a high-salt diet in SHRs resulted in exacerbation of hypertension and increased responses to air-jet stress and intracerebroventricular guanabenz. Losartan injected into the MnPO reversed the salt-sensitive component of the hypertension and normalized the depressor response to guanabenz but did not change responses to air-jet stress. We conclude that in the MnPO, ANG II via AT(1) receptors mediates cardiovascular responses to an acute increase in CSF sodium as well as the chronic pressor responses to high sodium intake in SHR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 06:01:44