Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Triglycerides impair postischemic recovery in isolated hearts: roles of endothelin-1 and trimetazidine
Autore:
Monti, LD; Allibardi, S; Piatti, PM; Valsecchi, G; Costa, S; Pozza, G; Chierchia, S; Samaja, M;
Indirizzi:
Hosp San Raffaele, IRCCS, Div Med, Dipartimento Cardiol, I-20132 Milan, Italy Hosp San Raffaele Milan Italy I-20132 ento Cardiol, I-20132 Milan, Italy Univ Vita Salute, Div Med, Unita Malattie Metab, I-20132 Milan, Italy UnivVita Salute Milan Italy I-20132 alattie Metab, I-20132 Milan, Italy Univ Vita Salute, Cattedra Clin Med Gen & Terapia Med, I-20132 Milan, Italy Univ Vita Salute Milan Italy I-20132 & Terapia Med, I-20132 Milan, Italy Univ Milan, Osped San Paolo, DiMCO, I-20090 Milan, Italy Univ Milan Milan Italy I-20090 ed San Paolo, DiMCO, I-20090 Milan, Italy
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 281, anno: 2001,
pagine: H1122 - H1130
SICI:
0363-6135(200109)281:3<H1122:TIPRII>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED RAT HEARTS; ISOLATED RABBIT HEARTS; FATTY-ACID OXIDATION; NITRIC-OXIDE; MYOCARDIAL-ISCHEMIA; REPERFUSION INJURY; DRUG TRIMETAZIDINE; DISEASE MORTALITY; IN-VIVO; CORONARY;
Keywords:
nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Monti, LD Hosp San Raffaele, IRCCS, Div Med, Dipartimento Cardiol, Via Olgettina 60,I-20132 Milan, Italy Hosp San Raffaele Via Olgettina 60 Milan Italy I-20132 n, Italy
Citazione:
L.D. Monti et al., "Triglycerides impair postischemic recovery in isolated hearts: roles of endothelin-1 and trimetazidine", AM J P-HEAR, 281(3), 2001, pp. H1122-H1130

Abstract

There is growing evidence that hypertriglyceridemia exacerbates ischemic injury. We tested the hypothesis that triglycerides impair myocardial recovery from low-flow ischemia in an ex vivo model and that such an effect is related to endothelin-1. Hyperglycemic (glucose concentration = 12 mmol/l) and hyperinsulinemic (insulin concentration = 1.2 mu mol/l) isolated rat hearts were perfused with Krebs-Henseleit buffer (PO2 = 670 mmHg, pH 7.4, 37 degreesC) added with increasing triglycerides (0, 1,000, 2,000, and 4,000 mg/dl, n = 6-9 rats/group). Hearts were exposed to 60 min of low-flow ischemia(10% of basal coronary flow), followed by 30 min of reperfusion. We found that increasing triglycerides impaired both the diastolic (P < 0.005) and systolic (P < 0.02) recovery. The release of endothelin-1 during reperfusionincreased linearly with triglyceride concentration (P = 0.0009). Elevated triglycerides also increased the release of nitrite and nitrate (NOx), the end products of nitric oxide, up to 6 mu mol/min. Trimetazidine (1 mu mol) further increased NOx release, blunted endothelin-1 release, and protected myocardial function during recovery. We conclude that high triglyceride levels impair myocardial recovery after low-flow ischemia in association with endothelin-1 release. The endothelium-mediated effect of triglycerides on both contractile recovery and endothelin-1 release is prevented by 1 muM trimetazidine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:14:43