Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
p53 nuclear accumulation and multiploidy are adverse prognostic factors insurgically resected stage II colorectal cancers independent of fluorouracil-based adjuvant therapy
Autore:
Buglioni, S; DAgnano, I; Vasselli, S; Donnorso, RP; DAngelo, C; Brenna, A; Benevelo, M; Cosimelli, M; Zupi, G; Mottolese, M;
Indirizzi:
Regina Elena Inst Canc Res, Dept Pathol, I-00144 Rome, Italy Regina Elena Inst Canc Res Rome Italy I-00144 athol, I-00144 Rome, Italy Regina Elena Inst Canc Res, Dept Surg 2, I-00144 Rome, Italy Regina Elena Inst Canc Res Rome Italy I-00144 urg 2, I-00144 Rome, Italy Regina Elena Inst Canc Res, Expt Chemotherapy Lab, I-00144 Rome, Italy Regina Elena Inst Canc Res Rome Italy I-00144 y Lab, I-00144 Rome, Italy
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 3, volume: 116, anno: 2001,
pagine: 360 - 368
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; DNA-PLOIDY; CLINICAL UTILITY; COLON-CARCINOMA; SURVIVAL; EXPRESSION; ADENOCARCINOMAS; PROTEIN; OVEREXPRESSION; CHEMOTHERAPY;
Keywords:
colorectal cancer; DNA multiploidy; p53; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Mottolese, M Regina Elena Inst Canc Res, Dept Pathol, Via Chianesi 53, I-00144 Rome, Italy Regina Elena Inst Canc Res Via Chianesi 53 Rome Italy I-00144
Citazione:
S. Buglioni et al., "p53 nuclear accumulation and multiploidy are adverse prognostic factors insurgically resected stage II colorectal cancers independent of fluorouracil-based adjuvant therapy", AM J CLIN P, 116(3), 2001, pp. 360-368

Abstract

To identify the prognostically highest risk patients, DNA content and p53 nuclear or cytoplastmic accumulation, evaluated by monoclonal antibody DO7 and polyclonal antibody CM1, were determined in 94 surgically resected stage II (Dukes B2) colorectal cancers, treated or not with adjuvant 5-fluorouracil-based chemotherapy. Sixty-one (65%) of the tumors were aneuploid, 16 (17%) of which had a multiploid DNA content; 50 (53%) displayed DO7 nuclear p53 accumulation, and 44(47%) showed cytoplasmic CM1 positivity. In multivariate analysis, only multiploidy and p53 nuclear positivity emerged as independent prognostic indicators of a poorer outcome. Positivity, for p53 was associated with shortersurvival in 5-fluorouracil-treated and untreated patients. Therefore, in patients with Dukes B2 colorectal cancer a biologic profile based on the combined evaluation of DNA multiploidy and p53 status can provide valuable prognostic information. identifying patients to be enrolled inalternative, more aggressive therapeutic trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:10:28