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Titolo:
Abnormal beta-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China
Autore:
Cui, J; Zhou, XD; Liu, YK; Tang, ZY; Zile, MH;
Indirizzi:
Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 Nutr, E Lansing, MI 48824 USA Fudan Univ, Zhongshan Hosp, Med Ctr, Liver Canc Inst, Shanghai 200032, Peoples R China Fudan Univ Shanghai Peoples R China 200032 nghai 200032, Peoples R China
Titolo Testata:
WORLD JOURNAL OF GASTROENTEROLOGY
fascicolo: 4, volume: 7, anno: 2001,
pagine: 542 - 546
SICI:
1007-9327(200108)7:4<542:ABGEWI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-CADHERIN EXPRESSION; PRIMARY LIVER-CANCER; ALPHA-CATENIN; GAMMA-CATENIN; COLORECTAL-CANCER; GASTRIC-CANCER; CELL-ADHESION; MUTATIONS; METASTASIS; MELANOMA;
Keywords:
hepatocellular carcinoma; wnt pathway; beta-catenin gene; metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Cui, J Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 E Lansing, MI 48824 USA
Citazione:
J. Cui et al., "Abnormal beta-catenin gene expression with invasiveness of primary hepatocellular carcinoma in China", WORLD J GAS, 7(4), 2001, pp. 542-546

Abstract

AIM To study the abnormal expression of beta -catenin gene and its relationship with invasiveness of primary hepatocellular carcinoma among Chinese people. METHODS Thirty-four hepatocellular carcinoma (HCC) specimens and adjacent para-cancerous tissues, 4 normal liver, tissues were immunohistochemically stained to study subcellular distribution of beta -catenin. Semiquantitive analysis of. expression of beta -catenin gene exon 3 mRNA was examined by RT-PCR and in situ hybridization. The relationship between expressions of both beta -catenin protein, mRNA and clinicopathological characteristics of HCC was also analyzed. RESULTS Immunohistochemistry showed that all normal liver tissues and para-cancerous tissues examined displayed membranous type staining for beta -catenin protein, occasionally with weak expression in the cytoplasm. While 21cases (61.8%) of HCC examined showed accumulated type in cytoplasms or nuclei. The accumuled type Labling Index ( LI) of cancer tissue and paracancarous tissue was ( 59.9 +/- 26.3) and ( 18.3 +/- 9.7) respectively (P <0.01). Higher accumulated type LI was closely related with invasiveness of HCG. Results of RT-PCR showed the beta -catenin gene exon 3 mRNA Expression Index(EI) of 34 HCCs was higher than that of para-cancerous tissue and normal liver tissue. Using in situ hybridization, the signal corresponding to beta -catenin gene exon 3 mRNA was particularly strong in Cytoplasm of HCC when compared with those of para-cancerous and normal liver tissues. Over expression of beta -catenin exon 3 was also found to be correlated with high metastatic potential of HCG. CONCLUSION Abnormal expression of beta -catenin gene may contribute importantly to the invasiveness of HCC among Chinese people.

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Documento generato il 07/04/20 alle ore 23:20:16