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Titolo:
Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa
Autore:
Shen, KZ; Koo, MWL; Cho, CH;
Indirizzi:
Univ Hong Kong, Fac Med, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200032, Peoples RChina Fudan Univ Shanghai Peoples R China 200032 anghai 200032, Peoples RChina
Titolo Testata:
WORLD JOURNAL OF GASTROENTEROLOGY
fascicolo: 4, volume: 7, anno: 2001,
pagine: 496 - 499
SICI:
1007-9327(200108)7:4<496:SDITEO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; NITRIC-OXIDE; CLINICAL IMPLICATIONS; MESSENGER-RNA; A-431 CELLS; INJURY; HEAT-SHOCK-PROTEIN-70; RESISTANCE; APOPTOSIS; PROTECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Koo, MWL Univ Hong Kong, Fac Med, Dept Pharmacol, 5 Sassoon Rd, Hong Kong,Hong Kong, Peoples R China Univ Hong Kong 5 Sassoon Rd Hong Kong Hong KongPeoples R China
Citazione:
K.Z. Shen et al., "Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa", WORLD J GAS, 7(4), 2001, pp. 496-499

Abstract

AIM To investigate if sleep deprivation is able to increase the expressionof inducible heat shock protein 70 in gastric mucosa and its possible rolein mucosal defense. METHODS Rats for sleep disruption were placed inside a computerized rotating drum, gastric mucosa was taken from rats with 1, 3 and 7 d sleep deprivation. RT-PCR, immunohistochemistry and Western blotting were used to determine the expression of heat shock protein 70. Ethanol ( 500 mL.L-1.i.g.) wasused to induce gastric mucosa damage. RESULTS RT-PCR, Western blotting and immunostaining confirmed that the sleep deprivation as a stress resulted in significantly greater expression of inducible heat shock protein 70 in gastric mucosa of rats. After the 500mL.L-1 ethanol challenge, the ulcer area found in the rats with 7 d sleep deprivation ( 19.15 +/- 4.2) mm(2) was significantly lower (P <0.01) than the corresponding control (53.7 +/- 8.1) mm(2). CONCLUSION Sleep deprivation as a stress, in addition to lowering the gastric mucosal barrier, is able to stimulate the expression of inducible heat shock protein 70 in gastric mucosa of rats, the heat shock protein 70 may play an important role in gastric mucosal protection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:09:31