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Titolo:
Opiate withdrawal during development: are NMDA receptors indispensable?
Autore:
Zhu, HB; Barr, GA;
Indirizzi:
CUNY Hunter Coll, Biopsychol Doctoral Program, Dept Psychol, New York, NY 10021 USA CUNY Hunter Coll New York NY USA 10021 pt Psychol, New York, NY 10021 USA CUNY, Grad Ctr, New York, NY 10021 USA CUNY New York NY USA 10021CUNY, Grad Ctr, New York, NY 10021 USA Columbia Univ Coll Phys & Surg, New York State Psychiat Inst, Div Dev Psychobiol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
TRENDS IN PHARMACOLOGICAL SCIENCES
fascicolo: 8, volume: 22, anno: 2001,
pagine: 404 - 408
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECIPITATED MORPHINE-WITHDRAWAL; CA2+-PERMEABLE AMPA RECEPTORS; IN-SITU HYBRIDIZATION; ISOLATED SPINAL-CORD; NEONATAL RAT; OPIOID TOLERANCE; GLUTAMATE RECEPTORS; DORSAL HORN; DEPENDENCE; EXPRESSION;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Zhu, HB CUNY Hunter Coll, Biopsychol Doctoral Program, Dept Psychol, 695 Pk Ave, New York, NY 10021 USA CUNY Hunter Coll 695 Pk Ave New York NY USA 10021 rk, NY 10021 USA
Citazione:
H.B. Zhu e G.A. Barr, "Opiate withdrawal during development: are NMDA receptors indispensable?", TRENDS PHAR, 22(8), 2001, pp. 404-408

Abstract

Despite decades of research, the mechanisms that underlie opiate tolerance, dependence and withdrawal remain elusive. Evidence accumulated over the past ten years suggests that the NMDA receptor plays a central role in mediating the neuroplasticity induced by chronic opiate administration in adult animals. Yet, during ontogeny, the NMDA receptor complex undergoes qualitative developmental changes, which renders some of the basic assumptions for a role of the NMDA receptor in opiate withdrawal invalid in infants. Recentdata indicate that NMDA receptor antagonists are not effective in blockingmorphine tolerance, dependence and withdrawal in the neonatal rat. Roles for other glutamate receptor types (e.g. metabotropic glutamate receptors) have also been proposed recently. In this article, the latest evidence that characterizes the dynamic roles of glutamate receptors in these phenomena during ontogeny will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:07:59