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Titolo:
Disease model: hyperinsulinemia and insulin resistance Part B - polygenic and other animal models
Autore:
Sone, H; Takahashi, A; Lida, K; Yamada, N;
Indirizzi:
Univ Tsukuba, Dept Internal Med, Inst Clin Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 8, volume: 7, anno: 2001,
pagine: 373 - 376
SICI:
1471-4914(200108)7:8<373:DMHAIR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; SPONTANEOUSLY HYPERTENSIVE RATS; TOKUSHIMA FATTY RAT; HYPERGLYCEMIC RAT; GENETIC-ANALYSIS; TRANSGENIC MICE; ADIPOSE-TISSUE; GK RAT; LEPTIN; MOUSE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Sone, H Univ Tsukuba, Dept Internal Med, Inst Clin Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki Japan 3058575 5, Japan
Citazione:
H. Sone et al., "Disease model: hyperinsulinemia and insulin resistance Part B - polygenic and other animal models", TRENDS MO M, 7(8), 2001, pp. 373-376

Abstract

Deficiency of leptin or its receptor produces hyperinsulinemia with markedobesity. Paradoxically, severe insulin resistance also accompanies lipodystrophy. Animal models of these contrasting conditions have enabled us to observe the profound and complicated aspects of the underlying pathologies. In addition, conventional polygenic rodents with known genetic backgrounds, such as the spontaneously hypertensive rat and the Goto-Kakisaki rat, have also been used to investigate these abnormalities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:57:34