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Titolo:
The calpain family and human disease
Autore:
Huang, YH; Wang, KKW;
Indirizzi:
Pfizer Global Res & Dev, Dept CNS Mol Sci, Lab Neurobiochem, Ann Arbor, MI48105 USA Pfizer Global Res & Dev Ann Arbor MI USA 48105 em, Ann Arbor, MI48105 USA
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 8, volume: 7, anno: 2001,
pagine: 355 - 362
SICI:
1471-4914(200108)7:8<355:TCFAHD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-DEPENDENT PROTEASE; CA-2+-ACTIVATED NEUTRAL PROTEASE; ELEGANS SEX DETERMINATION; MUSCLE-SPECIFIC CALPAIN; MESSENGER-RNA; MOLECULAR-CLONING; CRYSTAL-STRUCTURE; LARGE SUBUNIT; HIPPOCAMPAL-NEURONS; HUMAN HOMOLOG;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, YH Pfizer Global Res & Dev, Dept CNS Mol Sci, Lab Neurobiochem, 2800 PlymouthRd, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev 2800 PlymouthRd Ann Arbor MI USA 48105
Citazione:
Y.H. Huang e K.K.W. Wang, "The calpain family and human disease", TRENDS MO M, 7(8), 2001, pp. 355-362

Abstract

The number of mammalian calpain protease family members has grown to 14 onlast count. Overactivation of calpain 1 and calpain 2 (and their small subunit) has long been tied to acute neurological disorders (e.g. stroke and traumatic brain injury) and recently to Alzheimer's disease. Loss-of-function mutations of the calpain 3 gene have now been identified as the cause of limb-girdle muscular dystrophy 2A. Calpain 10 was recently identified as a susceptibility gene for type 2 diabetes, whereas calpain 9 appears to be a gastric cancer suppressor. This review describes our current understanding of the calpain family members and their mechanistic linkages to the aforementioned diseases as well as other emerging pathological conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:49:47