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Titolo:
How do neurons die in neurodegenerative diseases?
Autore:
Kanazawa, I;
Indirizzi:
Tokyo Univ Hosp, Dept Neurol, Tokyo 1138655, Japan Tokyo Univ Hosp TokyoJapan 1138655 p, Dept Neurol, Tokyo 1138655, Japan
Titolo Testata:
TRENDS IN MOLECULAR MEDICINE
fascicolo: 8, volume: 7, anno: 2001,
pagine: 339 - 344
SICI:
1471-4914(200108)7:8<339:HDNDIN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; CU,ZN SUPEROXIDE-DISMUTASE; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; HUNTINGTONS-DISEASE; OXIDATIVE STRESS; ALPHA-SYNUCLEIN; NIGRAL NEURONS; MUTATION; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kanazawa, I Tokyo Univ Hosp, Dept Neurol, Tokyo 1138655, Japan Tokyo Univ Hosp Tokyo Japan 1138655 ol, Tokyo 1138655, Japan
Citazione:
I. Kanazawa, "How do neurons die in neurodegenerative diseases?", TRENDS MO M, 7(8), 2001, pp. 339-344

Abstract

Given that neurons are post-mitotic cells, their life span is generally long enough to reach that of humans. However, sometimes neurons die without recognizable causes, as a result of a process called neurodegeneration. Apart from when gene mutations can be correlated with disease, it is difficult to pinpoint molecules that are responsible for neuronal death. Therefore, neurons living in a 'sick state' for many years might reveal important information about neuronal death. Systematic and extensive single-neuron analysis of 'sick' neurons is expected to provide clues to the mechanisms of neurodegeneration. Moreover, the elimination of putative triggering and promoting factors involved in neurodegenerative disease might prevent disease progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:57:50