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Titolo:
Protein-protein interaction maps: a lead towards cellular functions
Autore:
Legrain, P; Wojcik, J; Gauthier, JM;
Indirizzi:
Hybrigenics, F-75012 Paris, France Hybrigenics Paris France F-75012Hybrigenics, F-75012 Paris, France
Titolo Testata:
TRENDS IN GENETICS
fascicolo: 6, volume: 17, anno: 2001,
pagine: 346 - 352
SICI:
0168-9525(200106)17:6<346:PIMALT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOME-WIDE; SACCHAROMYCES-CEREVISIAE; ENU MUTAGENESIS; YEAST GENOME; DATABASE; NETWORKS; SCREENS; SYSTEM; MOUSE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Legrain, P Hybrigenics, 180 Ave Daumesnil, F-75012 Paris, France Hybrigenics 180 Ave Daumesnil Paris France F-75012 ris, France
Citazione:
P. Legrain et al., "Protein-protein interaction maps: a lead towards cellular functions", TRENDS GEN, 17(6), 2001, pp. 346-352

Abstract

The availability of complete genome sequences now permits the development of tools for functional biology on a proteomic scale. Several experimental approaches or in silico algorithms aim at clustering proteins into networkswith biological significance. Among those, the yeast two-hybrid system is the technology of choice to detect protein-protein interactions. Recently, optimized versions were applied at a genomic scale, leading to databases onthe web. However, as with any other 'genetic' assay, yeast two-hybrid assays are prone to false positives and false negatives. Here we discuss these various technologies, their general limitations and the potential advances they make possible, especially when in combination with other functional genomics or bioinformatics analyses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:24:13