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Titolo:
WHAT NITRATES TYROSINE - IS NITROTYROSINE SPECIFIC AS A BIOMARKER OF PEROXYNITRITE FORMATION IN-VIVO
Autore:
HALLIWELL B;
Indirizzi:
UNIV LONDON KINGS COLL,NEURODEGENERAT DIS RES CTR,MANRESA RD LONDON SW3 6LX ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 411, anno: 1997,
pagine: 157 - 160
SICI:
0014-5793(1997)411:2-3<157:WNT-IN>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ACUTE LUNG INJURY; SUPEROXIDE-DISMUTASE; OXIDATIVE DAMAGE; NITROGEN-DIOXIDE; CROSS-LINKING; IN-VIVO; PROTEINS; PLASMA; ELECTROPHORESIS;
Keywords:
PEROXYNITRITE; NITRIC OXIDE; NITROTYROSINE; NITROGEN DIOXIDE; HYPOCHLOROUS ACID; REACTIVE NITROGEN SPECIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
85
Recensione:
Indirizzi per estratti:
Citazione:
B. Halliwell, "WHAT NITRATES TYROSINE - IS NITROTYROSINE SPECIFIC AS A BIOMARKER OF PEROXYNITRITE FORMATION IN-VIVO", FEBS letters, 411(2-3), 1997, pp. 157-160

Abstract

Peroxynitrite (ONOO-) is a 'reactive nitrogen species' that can be formed (among other reactions) by combination of superoxide (O2(.-)) andnitric oxide (NO.) radicals. It is being increasingly proposed as a contributor to tissue injury in several human diseases. The evidence presented for peroxynitrite participation usually includes the demonstration of increased nitrotyrosine levels in the injured tissue. Indeed, this is often the only evidence presented: the assumption is that formation of nitrotyrosine is a biomarker specifically diagnostic of ONOO-production. The present article examines this assumption and concludes that nitrotyrosine is a biomarker for 'nitrating species' rather than being specific for ONOO-. (C) 1997 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:29:44