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Titolo:
Characteristics of anticoagulant therapy and comorbidity related to overanticoagulation
Autore:
Penning-van Beest, FJA; van Meegen, E; Rosendaal, FR; Stricker, BHC;
Indirizzi:
Erasmus Univ, Med Ctr, Dept Internal Med, Pharmacoepidemiol Unit, NL-3000 CA Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 CA CA Rotterdam, Netherlands Erasmus Univ, Med Ctr, Dept Epidemiol & Biostat, Pharmacoepidemiol Unit, NL-3000 CA Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 CA CA Rotterdam, Netherlands Red Cross Anticoagulat Clin, The Hague, Netherlands Red Cross AnticoagulatClin The Hague Netherlands he Hague, Netherlands Leiden Univ, Ctr Hemostasis & Thrombosis Res, Dept Clin Epidemiol, Med Ctr, The Hague, Netherlands Leiden Univ The Hague Netherlands miol, Med Ctr, The Hague, Netherlands Inspectorate Hlth Care, Drug Safety Unit, The Hague, Netherlands Inspectorate Hlth Care The Hague Netherlands it, The Hague, Netherlands
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 2, volume: 86, anno: 2001,
pagine: 569 - 574
SICI:
0340-6245(200108)86:2<569:COATAC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR RISK-FACTORS; COAGULATION-FACTOR-VII; WARFARIN ANTICOAGULATION; BLEEDING COMPLICATIONS; ORAL ANTICOAGULATION; INSTABILITY; POPULATION; FIBRINOGEN;
Keywords:
overanticoagulation; coumarin anticoagulants; incidence; comorbidity; characteristics of therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Stricker, BHC Erasmus Univ, Med Ctr, Dept Internal Med, Pharmacoepidemiol Unit, Room L448,POB 2040, NL-3000 CA Rotterdam, Netherlands Erasmus Univ Room L448,POB 2040 Rotterdam Netherlands NL-3000 CA
Citazione:
F.J.A. Penning-van Beest et al., "Characteristics of anticoagulant therapy and comorbidity related to overanticoagulation", THROMB HAEM, 86(2), 2001, pp. 569-574

Abstract

The risk of hemorrhage when using coumarin anticoagulants sharply increases when the International Normalised Ratio (INR) is greater than or equal to6.0. We performed a prospective cohort study with a nested case-control design among 17,056 outpatients of an anticoagulation clinic to determine the incidence of overanticoagulation and to study the association between overanticoagulation and characteristics of anticoagulant therapy and comorbidity. The incidence rate of an INR greater than or equal to6.0 was 7.8 per 10,000 treatment days in prevalent users on the starting date and 22.5 per 10,000 treatment days in incident users during the study period. 300 cases withan INR greater than or equal to6.0 were compared with 302 randomly selected matched controls with an INR within the target zone. Patients on acenocoumarol had an increased risk of an INR greater than or equal to6.0 compared to patients on phenprocoumon. Regarding comorbidity, impaired liver function, congestive heart failure, diarrhea and fever were risk factors for overanticoagulation. Increased monitoring of INR values if risk factors are present or avoidance of risk factors could prevent excess anticoagulation and potential bleeding complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:05:09