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Titolo:
Total synthesis of (-)-mniopetal F, a novel inhibitor of RNA-directed DNA-polymerases
Autore:
Suzuki, Y; Ohara, A; Sugaya, K; Takao, K; Tadano, K;
Indirizzi:
Keio Univ, Dept Appl Chem, Kokoku Ku, Yokohama, Kanagawa 2238522, Japan Keio Univ Yokohama Kanagawa Japan 2238522 kohama, Kanagawa 2238522, Japan
Titolo Testata:
TETRAHEDRON
fascicolo: 34, volume: 57, anno: 2001,
pagine: 7291 - 7301
SICI:
0040-4020(20010820)57:34<7291:TSO(FA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIELS-ALDER REACTION; TETRACYCLIC DECALIN PART; ASYMMETRIC-SYNTHESIS; REVERSE TRANSCRIPTASES; AZADIRACHTIN; MNIOPETALS; CONFIGURATION; CONSTRUCTION; INTERMEDIATE; COMPLEXES;
Keywords:
biologically active compounds; Diels-Alder reactions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Tadano, K Keio Univ, Dept Appl Chem, Kokoku Ku, 3-14-1 Hiyoshi, Yokohama, Kanagawa 2238522, Japan Keio Univ 3-14-1 Hiyoshi Yokohama Kanagawa Japan 2238522 , Japan
Citazione:
Y. Suzuki et al., "Total synthesis of (-)-mniopetal F, a novel inhibitor of RNA-directed DNA-polymerases", TETRAHEDRON, 57(34), 2001, pp. 7291-7301

Abstract

We have achieved a total synthesis of (-)-mniopetal F, a drimane-type sesquiterpenoid which inhibits the reverse transcriptase activity of the human immunodeficiency virus (HIV)-1. The key step in our enantiospecific synthesis is a stereoselective intramolecular Diels-Alder reaction, in which the Tr-facial selectivity is controlled by the stereoelectronic effect of a trialkylsilyloxy substituent existing adjacent to the dienophile part. (C) 2001Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:06:37