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Titolo:
BINDING OF MUTAGENIC HETEROCYCLIC AMINES BY INTESTINAL AND LACTIC-ACID BACTERIA
Autore:
ORRHAGE K; SILLERSTROM E; GUSTAFSSON JA; NORD CE; RAFTER J;
Indirizzi:
KAROLINSKA INST,HUDDINGE UNIV HOSP,DEPT MED NUTR,NOVUM F60 S-14186 HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE UNIV HOSP,DEPT MED NUTR S-14186 HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE UNIV HOSP,DEPT MICROBIOL S-14186 HUDDINGE SWEDEN
Titolo Testata:
Mutation research
fascicolo: 2, volume: 311, anno: 1994,
pagine: 239 - 248
SICI:
0027-5107(1994)311:2<239:BOMHAB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRIED GROUND-BEEF; GASTROINTESTINAL-TRACT; INVITRO BINDING; DIETARY FIBER; FOOD MUTAGEN; COLON CANCER; COOKED FOOD; MILK; ABSORPTION; PRODUCTS;
Keywords:
HETEROCYCLIC AMINE; MUTAGENIC PYROLYSATE; ANTIMUTAGENICITY; BACTERIAL BINDING; LACTIC ACID BACTERIA; INTESTINAL BACTERIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
K. Orrhage et al., "BINDING OF MUTAGENIC HETEROCYCLIC AMINES BY INTESTINAL AND LACTIC-ACID BACTERIA", Mutation research, 311(2), 1994, pp. 239-248

Abstract

Lactic acid bacteria have been reported to have antimutagenic/anticarcinogenic properties in vitro and in vivo. One possible mechanism for this effect involves a physical binding of the mutagenic compounds to the bacteria. The purpose of the present investigation was to study the binding capacity of eight human intestinal or lactic acid bacterial strains for mutagenic heterocyclic amines formed during cooking of protein-rich food. Binding of the mutagens Trp-P-2, PhIP, IQ and MeIQx bythe bacterial strains was analyzed by HPLC. There were only minor differences in the binding capacities of the tested strains but the mutagenic compounds were bound with markedly different efficiencies. Trp-P-2 was almost completely bound and the binding tended not to be of a reversible nature. The binding of PhIP, which reached about 50%, was important as PhIP is a major mutagen in the western diet. IQ and MeIQx were slightly less well bound. pH appeared to be of importance for the binding efficacy. Binding correlated well with the reduction in mutagenicity observed after exposure of the heterocyclic amines to the bacterial strains. The results indicate that cooked food mutagenic compounds, commonly found in the western meat-rich diet, can be bound to bacteria from the normal intestinal microflora in vitro.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:01:16