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Titolo:
Molecular evolution of chronic myeloid leukaemia
Autore:
Shteper, P; Ben-Yehuda, D;
Indirizzi:
Hadassah Univ Hosp, Dept Haematol, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 4, volume: 11, anno: 2001,
pagine: 313 - 322
SICI:
1044-579X(200108)11:4<313:MEOCML>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; BONE-MARROW TRANSPLANTATION; CHRONIC MYELOCYTIC-LEUKEMIA; BREAKPOINT CLUSTER REGION; ABL TYROSINE KINASE; P210 BCR-ABL; DNA METHYLATION; DISEASE PROGRESSION; CALCITONIN-GENE; C-ABL;
Keywords:
chronic myeloid leukaemia; progression; dormancy; methylation; ABL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Ben-Yehuda, D Hadassah Univ Hosp, Dept Haematol, POB 12000, IL-91120 Jerusalem, Israel Hadassah Univ Hosp POB 12000 Jerusalem Israel IL-91120 rael
Citazione:
P. Shteper e D. Ben-Yehuda, "Molecular evolution of chronic myeloid leukaemia", SEM CANC B, 11(4), 2001, pp. 313-322

Abstract

Chronic myeloid leukaemia (CML) is a clonal disorder of the pluripotent haematopoietic stem cell. The typical triphasic course of CML starts with thepremalignant chronic phase initiated by BCR-ABL hybrid oncogene formation. Secondary genetic and epigenetic aberrations accompany the progression to the accelerated phase and fatal blastic crisis. Properly timed bone marrow transplantation in eligible patients can result in durable remissions or cure. Both of these states are often accompanied by a long-term persistence of quiescent leukaemic cells. Accordingly, a 'functional cure' (i.e. tumour dormancy induction), rather than complete eradication of the malignant cells, is an adequate therapeutical goal. The level of the residual BCR-ABL-positive clones should be monitored and salvage treatment initiated whenever these quiescent leukaemic cells exit their dormant state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:06:28