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Titolo:
Biomedicine - A portrait of Alzheimer secretases - New features and familiar faces
Autore:
Esler, WP; Wolfe, MS;
Indirizzi:
Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 eurol Dis, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
SCIENCE
fascicolo: 5534, volume: 293, anno: 2001,
pagine: 1449 - 1454
SICI:
0036-8075(20010824)293:5534<1449:B-APOA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; NECROSIS-FACTOR-ALPHA; DISEASE-ASSOCIATED PRESENILIN-1; BETA-PEPTIDE PRODUCTION; FURIN-LIKE CONVERTASE; C-TERMINAL FRAGMENTS; GAMMA-SECRETASE; TRANSMEMBRANE DOMAIN; DISINTEGRIN-METALLOPROTEASE; ENDOGENOUS PRESENILIN-1;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Wolfe, MS Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Boston, MA 02115 USA
Citazione:
W.P. Esler e M.S. Wolfe, "Biomedicine - A portrait of Alzheimer secretases - New features and familiar faces", SCIENCE, 293(5534), 2001, pp. 1449-1454

Abstract

The amyloid beta -peptide (A beta) is a principal component of the cerebral plaques found in the brains of patients with Alzeheimer's disease (AD). This insoluble 40- to 42-amino acid peptide is formed by the cleavage of theA beta precursor protein (APP). The three proteases that cleave APP, alpha-, beta-, and gamma -secretases, have been implicated in the etiology of AD. beta -Secretase is a membrane-anchored protein with clear homology to soluble aspartyl proteases, and alpha -secretase displays characteristics of certain membrane-tethered metalloproteases. gamma -Secretase is apparently an oligomeric complex that includes the presenilins, which may be the catalytic component of this protease. Identification of the alpha-, beta-, and gamma -secretases provides potential targets for designing new drugs to treatAD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:56:57