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Titolo:
Vagus nerve stimulation - A new option for the treatment of chronic pain syndromes?
Autore:
Kirchner, A; Birklein, F; Stefan, H; Handwerker, HO;
Indirizzi:
Univ Erlangen Nurnberg, Neurol Klin, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Univ Erlangen Nurnberg, Inst Physiol & Expt Pathophysiol, Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany Pathophysiol, Erlangen, Germany
Titolo Testata:
SCHMERZ
fascicolo: 4, volume: 15, anno: 2001,
pagine: 272 - 277
SICI:
0932-433X(200108)15:4<272:VNS-AN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
GER
Soggetto:
VAGAL AFFERENT STIMULATION; REFRACTORY EPILEPSY; PARTIAL SEIZURES; NEURONS; NOCICEPTION; MODULATION; REFLEX; HYPERALGESIA; INHIBITION; THRESHOLDS;
Keywords:
vagus nerve stimulation; antinociception; psychophysics; experimental pain;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Birklein, F Univ Erlangen Nurnberg, Neurol Klin, Schwabachanlage 6, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Schwabachanlage 6 Erlangen Germany D-91054
Citazione:
A. Kirchner et al., "Vagus nerve stimulation - A new option for the treatment of chronic pain syndromes?", SCHMERZ, 15(4), 2001, pp. 272-277

Abstract

Electrical stimulation of the vagal nerve (VNS) has become an established method for treating medically refractory epilepsies. From animal experiments it is well known that depending on the stimulation intensity VNS can elicit both inhibition and facilitation of nociception. Recent physiologic investigations demonstrated a similar influence of VNS on pain perception in patients treated by chronic VNS. However, in humans, a more marked effect wasshown for the pain inhibition which is probably mediated by neurobiochemical mechanisms. These findings are discussed in consideration of the physiologic mechanisms underlying the modulation of pain and seizures by VNS knownfrom animal studies. First reports of attenuation of chronic pain by VNS indicate that the method might be an option for pain treatment in the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:22:05