Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Flutamide-induced hepatotoxicity: report of a case series
Autore:
Cortes, MG; Andrade, RJ; Lucena, MI; Martinez, HS; Fernandez, MC; Ferrer, T; Martin-Vivaldi, R; Pelaez, G; Suarez, F; Rosemary-Gomez, M; Montero, JL; Fraga, E; Camargo, R; Alcantara, R; Pizarro, MA; Garcia-Ruiz, E;
Indirizzi:
Univ Hosp Virgen Victoria, Hepatol Unit, Digest Serv, Malaga, Spain Univ Hosp Virgen Victoria Malaga Spain Unit, Digest Serv, Malaga, Spain Univ Hosp Virgen Victoria, Hepatol Unit, Clin Pharmacol Serv, Malaga, Spain Univ Hosp Virgen Victoria Malaga Spain in Pharmacol Serv, Malaga, Spain Hosp La Inmaculada, Digest Unit, Almeria, Spain Hosp La Inmaculada Almeria Spain nmaculada, Digest Unit, Almeria, Spain Hosp Torrecardenas, Clin Pharmacol Unit, Almeria, Spain Hosp Torrecardenas Almeria Spain s, Clin Pharmacol Unit, Almeria, Spain Hosp Torrecardenas, Digest Serv, Almeria, Spain Hosp Torrecardenas Almeria Spain ecardenas, Digest Serv, Almeria, Spain Hosp Juan Ramon Jimenez, Digest Serv, Huelva, Spain Hosp Juan Ramon Jimenez Huelva Spain imenez, Digest Serv, Huelva, Spain Hosp Virgen Nieves, Digest Serv, Granada, Spain Hosp Virgen Nieves Granada Spain en Nieves, Digest Serv, Granada, Spain Hosp Virgen Valme, Digest Serv, Seville, Spain Hosp Virgen Valme SevilleSpain rgen Valme, Digest Serv, Seville, Spain Hosp Reina Sofia, Digest Serv, Cordoba, Spain Hosp Reina Sofia Cordoba Spain Reina Sofia, Digest Serv, Cordoba, Spain
Titolo Testata:
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
fascicolo: 7, volume: 93, anno: 2001,
pagine: 428 - 432
SICI:
1130-0108(200107)93:7<428:FHROAC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FULMINANT HEPATIC-FAILURE; LIVER TOXICITY; PROSTATE-CANCER; HIRSUTISM; CARCINOMA; THERAPY;
Keywords:
hepatotoxicity; flutamide; non-steroidal antiandrogens; fulminant liver failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Andrade, RJ Fac Med, Unidad Hepatol, Dept Med, Campus Univ Teatinos S-N, Malaga 29071,Spain Fac Med Campus Univ Teatinos S-N Malaga Spain 29071 071,Spain
Citazione:
M.G. Cortes et al., "Flutamide-induced hepatotoxicity: report of a case series", REV ESP E D, 93(7), 2001, pp. 428-432

Abstract

Objective: to evaluate the characteristics of flutamide induced hepatotoxicity. Material and methods: in this retrospective study we have analyzed all cases of flutamide hepatotoxicity submitted to the Andalucian Registry of drug-induced liver disease. Data were collected using a structured reporting form. Causality assessment was performed using two clinical scales: the standard CIOMS scale and the recently developed Maria and Victorino scale. Results: nine of 185 patients (4.9%) were identified. In 8 male patients, mean age 75 years (range 65-83), flutamide was indicated for palliative therapy of disseminated prostatic carcinoma, and in one young female (14 years) was given for the treatment of facial hirsutism. The mean duration of theflutamide therapy was 151 days (range 4-443). All patients presented with overt liver injury, the most frequent features being asthenia, anorexia, weight loss, nausea, vomiting and jaundice. No patient showed hypersensitivity features. In two patients (22%) the hepatic damage evolved to fulminant liver failure, one of them undergoing a liver transplantation and the other subsequently died. An additional patient died of a non-hepatic related cause when his liver function was improving. Causality assessment by the two clinical scales did not exclude any case, but the two patients who died whereclassified as unlikely by the Maria and Victorino scale. Conclusions: flutamide can induce severe acute hepatitis, probably due to an idiosyncratic metabolic mechanism. Liver tests monitoring should probably be mandatory during the first months of flutamide therapy and the drug withdrawn if transaminases began to increase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 20:25:54