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Titolo:
Eosinophil cationic protein (ECP) in saliva: a new marker of disease activity in bronchial asthma
Autore:
Schmekel, B; Ahlner, J; Malmstrom, M; Venge, P;
Indirizzi:
Linkoping Univ Hosp, Dept Clin Physiol, Inst Med & Care, S-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden S-58185 , S-58185 Linkoping, Sweden Natl Board Forens Med, Linkoping, Sweden Natl Board Forens Med LinkopingSweden rd Forens Med, Linkoping, Sweden R&D Dept, Primary Care Unit, Mjolby, Sweden R&D Dept Mjolby SwedenR&D Dept, Primary Care Unit, Mjolby, Sweden Univ Uppsala Hosp, Dept Clin Chem, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 n Chem, S-75185 Uppsala, Sweden
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 8, volume: 95, anno: 2001,
pagine: 670 - 675
SICI:
0954-6111(200108)95:8<670:ECP(IS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED SPUTUM; AIRWAY INFLAMMATION; HEALTHY-SUBJECTS; ATOPIC ASTHMA; LUNG-FUNCTION; FORCED OSCILLATION; REFERENCE VALUES; FUNCTION TESTS; COLD-AIR; HYPERRESPONSIVENESS;
Keywords:
eosinophil cationic protein (ECP); saliva; asthma; bronchial hyper-responsiveness to isocapnic hyperventilation of dry cold air; forced oscillation technique;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Schmekel, B Linkoping Univ Hosp, Dept Clin Physiol, Inst Med & Care, S-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden S-58185 nkoping, Sweden
Citazione:
B. Schmekel et al., "Eosinophil cationic protein (ECP) in saliva: a new marker of disease activity in bronchial asthma", RESP MED, 95(8), 2001, pp. 670-675

Abstract

Eosinophil cells play a crucial role in the pathogenesis of asthma, and concentration of eosinophil cationic protein (ECP) in serum has been used to monitor activity of the disease. Our aim was to determine the feasibility and usefulness of measuring ECP in saliva and to use it as a marker of the disease, Thirty-eight patients with asthma and 16 healthy volunteers were included in this study. Repeatability of measurements of ECP in saliva was acceptable [intra-class correlation coefficients (Ri) = 0.74 and coefficientsof repeatability (CR) = 0.37 in five healthy subjects]. Levels of ECP in saliva were higher in asthmatics than in volunteers (P < 0.01). There was a significant inverse association between a surrogate variable reflecting disease activity (i.e, change over a few weeks in dose of inhaled corticosteroid required by a change in clinical status of asthma) and a change over thesame time period in salivary ECP in 19 patients with stable asthma (r = -0-64, P = 0.02). Our findings indicate that levels of salivary ECP are elevated in patients with asthma and associated with presumed activity of disease as recorded by alteration of taken dose of inhaled corticosteroid. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:52:21