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Titolo:
Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats
Autore:
Stunden, CE; Filosa, JA; Garcia, AJ; Dean, JB; Putnam, RW;
Indirizzi:
Wright State Univ, Sch Med, Dept Physiol & Biophys, Dayton, OH 45435 USA Wright State Univ Dayton OH USA 45435 iol & Biophys, Dayton, OH 45435 USA
Titolo Testata:
RESPIRATION PHYSIOLOGY
fascicolo: 2-3, volume: 127, anno: 2001,
pagine: 135 - 155
SICI:
0034-5687(200109)127:2-3<135:DOIVVA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS NEURONS; NUCLEUS-TRACTUS-SOLITARII; BRAIN-STEM; CARBON-DIOXIDE; NEWBORN RATS; RESPIRATORY RESPONSES; POSTNATAL-DEVELOPMENT; BREATHING PATTERN; NIGHT DIFFERENCES; INTRACELLULAR PH;
Keywords:
carbon dioxide; response; chemosensitivity; CO2 response; control of breathing; central chemosensitivity; development; neonatal vs. adult; CO2 response; mammals; rat; nucleus; locus coeruleus pattern of breathing; CO2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Putnam, RW Wright State Univ, Sch Med, Dept Physiol & Biophys, 3640 Colonel Glenn Highway, Dayton, OH 45435 USA Wright State Univ 3640 Colonel Glenn Highway Dayton OH USA 45435
Citazione:
C.E. Stunden et al., "Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats", RESP PHYSL, 127(2-3), 2001, pp. 135-155

Abstract

We used pressure plethysmography to study breathing patterns of neonatal and adult rats acutely exposed to elevated levels of CO2. Ventilation (V over dotE) increased progressively with increasing inspired CO2. The rise in Vover dotE was associated with an increase in tidal volume, but not respiratory rate. In all animals studied, the CO2 sensitivity (determined from theslope of the V over dotE vs. inspired % CO2 curve) was variable on a day to day basis. Chemosensitivity was high in neonates I day after birth (PI) and fell throughout the first week to a minimum at about P8. Chemosensitivity rose again to somewhat higher values in P10 through adult rats. The developmental pattern of these in vivo ventilatory responses was different than individual locus coeruleus (LQ neuron responses to increased CO2. The membrane potential (V-m) of LC neurons was measured using perforated patch (amphotericin B) techniques in brain slices. At all ages studied, LC neurons increased their firing rate by similar to 44% in response to hypercapnic acidosis (10% CO2, pH 7.0). Thus the in vivo ventilatory response to hypercapniawas not correlated with the V-m response of individual LC neurons to hypercapnic acidosis in neonatal rats. These data suggest that CO2 sensitivity of ventilation in rats may exist in two forms, a high-sensitivity neonatal (or fetal) form and a lower-sensitivity adult form, with a critical window of very low sensitivity during the period of transition between the two (similar to P8). (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 21/09/20 alle ore 16:07:22